School of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao 266021, China.
School of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao 266021, China.
J Affect Disord. 2024 Aug 15;359:70-77. doi: 10.1016/j.jad.2024.05.049. Epub 2024 May 10.
The triglyceride glucose (TyG) index, a novel surrogate indicator for insulin resistance (IR), is believed to be associated with various diseases. However, its connection with cognitive decline remains controversy.
The PubMed, EMBASE, Cochrane Library, Web of Science, and Medline databases were systematically searched up to October 2023 to assess the association between the TyG index and the risk of cognitive decline. Effect estimates and 95 % confidence intervals (CIs) were calculated using a random-effects model.
Our review included 3 cohort studies and 9 case-control/cross-sectional studies with a total of 5,603,350 participants. In comparison to a low TyG index, a higher TyG index was connected to an elevated risk of cognitive decline (RR/HR = 1.14, 95 % CI [1.11, 1.17], P < 0.05; OR = 1.75, 95 % CI [1.34, 2.29], P < 0.05). Furthermore, the dose-response analysis from the case-control/cross-sectional studies revealed a 1.42 times higher risk of cognitive decline per 1 mg/dl increment of the TyG index (OR = 1.42, 95 % CI [1.19, 1.69], P < 0.05).
The inclusion of observational studies in the meta-analysis demonstrated a lower hierarchy of evidence compared to randomized controlled trials. Moreover, we incorporated a restricted number of studies and identified significant heterogeneity among them, potentially attributed to the presence of numerous confounding variables.
TyG index is related to cognitive decline. In view of some of the limitations of this study, further research will be necessary to confirm this relationship.
甘油三酯-葡萄糖（TyG）指数是一种新的胰岛素抵抗（IR）替代指标，与各种疾病有关。然而，它与认知能力下降的关系仍存在争议。
系统检索了 PubMed、EMBASE、Cochrane 图书馆、Web of Science 和 Medline 数据库，截至 2023 年 10 月，以评估 TyG 指数与认知能力下降风险之间的关系。使用随机效应模型计算效应估计值和 95%置信区间（CI）。
我们的综述纳入了 3 项队列研究和 9 项病例对照/横断面研究，共纳入 5603350 名参与者。与低 TyG 指数相比，较高的 TyG 指数与认知能力下降的风险增加相关（RR/HR=1.14，95%CI[1.11,1.17]，P<0.05；OR=1.75，95%CI[1.34,2.29]，P<0.05）。此外，来自病例对照/横断面研究的剂量-反应分析显示，TyG 指数每增加 1mg/dl，认知能力下降的风险增加 1.42 倍（OR=1.42，95%CI[1.19,1.69]，P<0.05）。
荟萃分析中纳入的观察性研究与随机对照试验相比，证据层次较低。此外，我们纳入的研究数量有限，且研究之间存在显著异质性，这可能归因于存在许多混杂因素。
TyG 指数与认知能力下降有关。鉴于本研究的一些局限性，需要进一步的研究来证实这种关系。
