School of Life Sciences, Jiangsu University, Zhenjiang, 212013, China.
Jiangsu Provincial Health Development Research Center, Nanjing, 210003, China.
ChemMedChem. 2024 Aug 19;19(16):e202400021. doi: 10.1002/cmdc.202400021. Epub 2024 Jun 19.
Cervical cancer seriously affects the health of women worldwide. Persistent infection of high-risk HPV (Human Papilloma Virus) can lead to cervical cancer. There is a great need for timely and efficient screening methods for cervical cancer. The current screening methods for cervical cancer are mainly based on cervical cytology and HPV testing. Cervical cytology is made of Pap smear and liquid-based cytology, while HPV testing is based on immunological and nucleic acid level detection methods. This review introduces cervical cancer screening methods based on cytology and human papillomavirus testing in detail. The advantages and limitations of the screening methods are also summarized and compared.
宫颈癌严重影响全球女性的健康。高危型 HPV(人乳头瘤病毒)的持续感染可导致宫颈癌。因此,迫切需要及时、有效的宫颈癌筛查方法。目前宫颈癌的筛查方法主要基于宫颈细胞学和 HPV 检测。宫颈细胞学包括巴氏涂片和液基细胞学,而 HPV 检测则基于免疫学和核酸水平的检测方法。本文详细介绍了基于细胞学和 HPV 检测的宫颈癌筛查方法,并对其优缺点进行了总结和比较。