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肾移植受者预防复发性膜性肾病的移植前治疗:一例报告

Pretransplant Treatment to Avoid Recurrent Membranous Nephropathy in a Kidney Transplant Recipient: A Case Report.

作者信息

Lum Erik L, Zuckerman Jonathan E, Abdelnour Lama, Terenzini Jennifer, Singh Gurbir, Bunnapradist Suphamai

机构信息

Division of Nephrology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California.

Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, California.

出版信息

Kidney Med. 2024 Apr 12;6(6):100822. doi: 10.1016/j.xkme.2024.100822. eCollection 2024 Jun.

Abstract

Kidney transplant candidates with high anti-M-type phospholipase A2 receptor antibody activity may be at increased risk for early postkidney transplant recurrence and allograft loss. Pretransplant treatment to induce serological remission may be warranted to improve allograft survival. In this case report, a patient seeking their third kidney transplant, who lost 2 prior living donor transplants from early recurrent membranous nephropathy, underwent pretransplant treatment for membranous nephropathy with serological remission and no evidence of recurrent disease.

摘要

抗M型磷脂酶A2受体抗体活性高的肾移植候选者在肾移植后早期复发和移植肾丢失的风险可能会增加。进行移植前治疗以诱导血清学缓解可能有助于提高移植肾存活率。在本病例报告中,一名寻求第三次肾移植的患者,其前两次活体供肾移植均因早期复发性膜性肾病而失败,该患者接受了针对膜性肾病的移植前治疗,实现了血清学缓解且无疾病复发迹象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/55eb/11078694/c69a524c0b4c/gr1.jpg

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