Reproductive Medicine Center, Henan Provincial People's Hospital, Zhengzhou, China.
Reproductive Medicine Center, Zhengzhou University People's Hospital, Zhengzhou, China.
Front Endocrinol (Lausanne). 2024 Apr 26;15:1378635. doi: 10.3389/fendo.2024.1378635. eCollection 2024.
The objective of this study is to investigate the factors that influence the live birth rate (LBR) of the first single euploid frozen-thawed blastocyst transfer (FBT) cycles after preimplantation genetic testing for structural rearrangements (PGT-SR) in couples with balanced chromosomal translocations (BCT).
Single center, retrospective and observational study.
A total of 336 PGT-SR and the first single euploid FBT cycles between July 2016 and December 2022 were included in this study. The patients were divided into two groups according to the live birth outcomes. The parameters of the study population, controlled ovarian stimulation cycles, and FBT cycles were analyzed. Multivariable binary logistic regression was performed to find the factors that affected the LBR.
The percentage of blastocysts at developmental stage Day 5 compared to Day 6 (51.8% vs. 30.8%; P<0.001) and with morphology ≥BB compared to <BB (49.7% vs. 32.2%; P=0.001) was significantly different between the group that resulted in live births (n=193) and the group that did not (n=143). The results of the multivariable binary logistic regression analysis indicated that the developmental stage (adjusted OR: 2.068, 95%CI 1.291-3.313; P=0.003) and morphology (adjusted OR: 1.697, 95%CI 1.039-2.773; P=0.035) of the blastocyst were significantly correlated with live birth. Patients with blastocysts that reached the developmental stage at Day 5 and had a morphology of ≥BB had a higher likelihood of having a live birth.
The developmental stage and morphology of blastocyst affect the live birth outcome of the first single euploid FBT in BCT carriers undergoing PGT-SR.
本研究旨在探讨在携带平衡染色体易位（BCT）的夫妇中，进行胚胎植入前遗传学检测结构重排（PGT-SR）后的第一次单囊胚冻融移植（FBT）周期中，影响活产率（LBR）的因素。
单中心、回顾性和观察性研究。
本研究共纳入了 2016 年 7 月至 2022 年 12 月期间的 336 个 PGT-SR 和第一次单囊胚冻融移植周期。根据活产结局将患者分为两组。分析研究人群的参数、控制性卵巢刺激周期和 FBT 周期。采用多变量二项逻辑回归分析影响 LBR 的因素。
第 5 天的囊胚发育阶段（51.8%对 30.8%；P<0.001）和形态学评分≥BB（49.7%对 32.2%；P=0.001）与活产组（n=193）和非活产组（n=143）之间存在显著差异。多变量二项逻辑回归分析结果表明，囊胚的发育阶段（调整后的 OR：2.068，95%CI 1.291-3.313；P=0.003）和形态学（调整后的 OR：1.697，95%CI 1.039-2.773；P=0.035）与活产显著相关。囊胚发育到第 5 天且形态学评分≥BB 的患者活产的可能性更高。
在进行 PGT-SR 的 BCT 携带者中，囊胚的发育阶段和形态学影响第一次单囊胚冻融移植周期的活产结局。
