Soga Rika, Okada Yosuke, Tanaka Kenichi, Koikawa Kenji, Tanaka Yoshiya
First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, JPN.
Cureus. 2024 Apr 10;16(4):e57952. doi: 10.7759/cureus.57952. eCollection 2024 Apr.
We report two rare cases of painful thyroiditis approximately 100 days after unrelated cord blood transplantation (CBT), which progressed to hypothyroidism. Patient one, a 45-year-old woman, developed goiter, tenderness, and thyrotoxicity on day 100 after CBT for relapsed acute lymphocytic leukemia. Scintigraphy suggested destructive thyroiditis; symptoms improved with one-month beta-blocker and prednisolone treatment. Two months later, hypothyroidism developed which required supplementation-based treatment. Patient two, a 49-year-old man, developed goiter, tenderness, and thyrotoxicosis on day 96 after CBT for acute myelogenous leukemia. Hypothyroidism developed after nonsteroidal anti-inflammatory drug treatment. Thyroiditis and hypothyroidism should be considered in patients who develop neck pain after CBT.
我们报告了两例无关脐血移植（CBT）后约100天发生的疼痛性甲状腺炎罕见病例，两例均进展为甲状腺功能减退。病例一为一名45岁女性，在因复发性急性淋巴细胞白血病接受CBT后第100天出现甲状腺肿大、压痛和甲状腺毒症。闪烁扫描提示为破坏性甲状腺炎；经一个月的β受体阻滞剂和泼尼松龙治疗后症状改善。两个月后，出现甲状腺功能减退，需要进行替代治疗。病例二为一名49岁男性，在因急性髓性白血病接受CBT后第96天出现甲状腺肿大、压痛和甲状腺毒症。经非甾体抗炎药治疗后出现甲状腺功能减退。CBT后出现颈部疼痛的患者应考虑甲状腺炎和甲状腺功能减退。
