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丁螺环酮改善选择性5-羟色胺再摄取抑制剂相关性性功能障碍：证据审查

Improvement in Selective Serotonin Reuptake Inhibitor-Associated Sexual Dysfunction With Buspirone: Examining the Evidence.

作者信息

Lipman Kyra, Betterly Holly, Botros Mousa

机构信息

Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, USA.

出版信息

Cureus. 2024 Apr 10;16(4):e57981. doi: 10.7759/cureus.57981. eCollection 2024 Apr.

DOI:10.7759/cureus.57981
PMID:38738086
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11087012/
Abstract

Sexual dysfunction is a common problem for patients taking antidepressants, with the highest prevalence rates observed with selective serotonin reuptake inhibitors (SSRIs). Sexual dysfunction can be distressing for patients and may lead to medication non-adherence; thus, it is important for the prescribers to be aware of the available treatment strategies, as well as of the strength of the evidence that supports their use. We present the case of a patient who developed delayed ejaculation after the initiation of sertraline for the treatment of depression. The patient's sexual dysfunction resolved after the addition of buspirone. A discussion of this case is followed by a review of the existing literature examining the possible role of buspirone in the treatment of SSRI-induced sexual dysfunction.

摘要

性功能障碍是服用抗抑郁药患者的常见问题，其中选择性5-羟色胺再摄取抑制剂（SSRI）引发的患病率最高。性功能障碍会令患者苦恼，并可能导致不遵医嘱服药；因此，开处方者了解可用的治疗策略以及支持这些策略使用的证据强度非常重要。我们报告一例患者，其在开始使用舍曲林治疗抑郁症后出现射精延迟。加用丁螺环酮后，该患者的性功能障碍得到缓解。在对该病例进行讨论之后，我们回顾了现有文献，探讨丁螺环酮在治疗SSRI引起的性功能障碍中可能发挥的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714c/11087012/d23905eb3ae3/cureus-0016-00000057981-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714c/11087012/a1d623a338d8/cureus-0016-00000057981-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714c/11087012/d23905eb3ae3/cureus-0016-00000057981-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714c/11087012/a1d623a338d8/cureus-0016-00000057981-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/714c/11087012/d23905eb3ae3/cureus-0016-00000057981-i02.jpg

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本文引用的文献

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Paroxetine in the treatment of premature ejaculation: a systematic review and meta-analysis.帕罗西汀治疗早泄：一项系统评价与荟萃分析
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Effect of buspirone on sexual dysfunction in depressed patients treated with selective serotonin reuptake inhibitors.丁螺环酮对接受选择性5-羟色胺再摄取抑制剂治疗的抑郁症患者性功能障碍的影响。
J Clin Psychopharmacol. 1999 Jun;19(3):268-71. doi: 10.1097/00004714-199906000-00012.
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Mechanism of action of serotonin selective reuptake inhibitors. Serotonin receptors and pathways mediate therapeutic effects and side effects.血清素选择性再摄取抑制剂的作用机制。血清素受体和通路介导治疗效果和副作用。
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Comparative sexual side effects of bupropion, fluoxetine, paroxetine, and sertraline.安非他酮、氟西汀、帕罗西汀和舍曲林的性副作用比较
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