Higgins Agnes, Nash Michael, Lynch Aileen M
School of Nursing and Midwifery Studies, Trinity College Dublin, Dublin, Ireland.
Drug Healthc Patient Saf. 2010;2:141-50. doi: 10.2147/DHPS.S7634. Epub 2010 Sep 9.
Sexual dysfunction is a common side effect of antidepressants and can have significant impact on the person's quality of life, relationships, mental health, and recovery. The reported incidence of sexual dysfunction associated with antidepressant medication varies considerably between studies, making it difficult to estimate the exact incidence or prevalence. The sexual problems reported range from decreased sexual desire, decreased sexual excitement, diminished or delayed orgasm, to erection or delayed ejaculation problems. There are a number of case reports of sexual side effects, such as priapism, painful ejaculation, penile anesthesia, loss of sensation in the vagina and nipples, persistent genital arousal and nonpuerperal lactation in women. The focus of this article is to explore the incidence, pathophysiology, and treatment of antidepressant iatrogenic sexual dysfunction.
性功能障碍是抗抑郁药常见的副作用，会对患者的生活质量、人际关系、心理健康及康复产生重大影响。不同研究报道的与抗抑郁药相关的性功能障碍发生率差异很大，因此难以准确估计其确切发病率或患病率。所报道的性问题包括性欲减退、性兴奋降低、性高潮减弱或延迟、勃起或射精延迟问题。还有一些关于性副作用的病例报告，如阴茎异常勃起、射精疼痛、阴茎麻木、阴道和乳头感觉丧失、女性持续性性唤起及非产褥期泌乳。本文的重点是探讨抗抑郁药医源性性功能障碍的发生率、病理生理学及治疗方法。
