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细胞培养中后期的分析：一种区分选择性改变染色体结构或有丝分裂装置的化合物的合适测试系统。

Analysis of anaphase in cell culture: an adequate test system for the distinction between compounds which selectively alter the chromosome structure or the mitotic apparatus.

作者信息

Coutiño R R

出版信息

Environ Health Perspect. 1979 Aug;31:131-6. doi: 10.1289/ehp.31-1637635.

DOI:10.1289/ehp.31-1637635
PMID:387394
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1637635/
Abstract

A system of anaphase analysis is presented as an adequate test to detect aberrations in chromosome structure and alterations in the mitotic apparatus. Particular emphasis is placed on those data which suggest that proteins may be the preferred targets of chemical compounds that induce aneuploidy.

摘要

提出了一种后期分析系统，作为检测染色体结构畸变和有丝分裂装置改变的适当测试。特别强调了那些表明蛋白质可能是诱导非整倍体的化合物的首选靶点的数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0156/1637635/1b5b10eabb3a/envhper00476-0132-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0156/1637635/1b5b10eabb3a/envhper00476-0132-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0156/1637635/1b5b10eabb3a/envhper00476-0132-a.jpg

相似文献

1
Analysis of anaphase in cell culture: an adequate test system for the distinction between compounds which selectively alter the chromosome structure or the mitotic apparatus.细胞培养中后期的分析：一种区分选择性改变染色体结构或有丝分裂装置的化合物的合适测试系统。
Environ Health Perspect. 1979 Aug;31:131-6. doi: 10.1289/ehp.31-1637635.
2
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本文引用的文献

1
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2
The inhibition of mitosis by the reaction of maleic hydrazide with sulphydryl groups.马来酰肼与巯基反应对有丝分裂的抑制作用。
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Arsenic as an inhibitor of the enzymes concerned in cellular recovery (dark repair).
砷作为细胞恢复（暗修复）相关酶的抑制剂。
Ger Med Mon. 1969 Dec;14(12):614-6.
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Studies of radiocalcium efflux in single barnacle muscle fibres: effects of procaine and external divalent cations.藤壶单根肌纤维放射性钙外流的研究：普鲁卡因和细胞外二价阳离子的作用。
J Physiol. 1974 Apr;238(2):313-28. doi: 10.1113/jphysiol.1974.sp010526.
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The membrane actions of anesthetics and tranquilizers.麻醉剂和镇静剂的膜作用。
Pharmacol Rev. 1972 Dec;24(4):583-655.
7
Effects of ethidium bromide on mitosis and chromosomes: a possible material basis for chromosome stickiness.
Chromosoma. 1974;47(2):157-66. doi: 10.1007/BF00331803.
8
Role of tubulin-SH groups in polymerization to microtubules. Functional-SH groups in tubulin for polymerization.微管蛋白-SH基团在聚合成微管中的作用。微管蛋白中参与聚合的功能性-SH基团。
J Biochem. 1974 Sep;76(3):651-4. doi: 10.1093/oxfordjournals.jbchem.a130609.
9
Influence of thiol-inhibiting substances on the effects of ethyl methane sulphonate (EMS) on chromosomes.硫醇抑制物质对甲磺酸乙酯（EMS）染色体效应的影响。
Experientia. 1965 Apr 15;21(4):200-2. doi: 10.1007/BF02141884.
10
Characterisation of the lysosomal heterogeneity in Chinese-hamster fibroblasts.中国仓鼠成纤维细胞中溶酶体异质性的表征
Eur J Biochem. 1976 Jun 1;65(2):341-8. doi: 10.1111/j.1432-1033.1976.tb10347.x.