Carmichael J, Cornbleet M A, MacDougall R H, Allan S G, Duncan W, Chisholm G D, Smyth J F
Br J Urol. 1985 Jun;57(3):299-302. doi: 10.1111/j.1464-410x.1985.tb06348.x.
Nineteen patients with recurrent or metastatic transitional cell carcinoma of the urinary tract were treated with a 3-weekly combination of methotrexate 200 mg/m2 as a 24-h infusion with folinic acid rescue and cis-platin 100 mg/m2. An objective response rate of 68% was obtained, with 4 patients (21%) achieving complete remission. Pulmonary disease and lymph node metastases were particularly sensitive to this therapy. The median duration of response was 21 weeks with a median survival of 54 weeks in the responding patients. This regimen warrants further investigation in the treatment of invasive bladder carcinoma.
19例复发性或转移性泌尿道移行细胞癌患者接受了如下治疗：每3周联合使用甲氨蝶呤200mg/m²，24小时静脉输注，并使用亚叶酸钙解救，以及顺铂100mg/m²。客观缓解率为68%，4例患者（21%）实现完全缓解。肺部疾病和淋巴结转移对该治疗尤为敏感。缓解患者的中位缓解持续时间为21周，中位生存期为54周。该方案值得在浸润性膀胱癌的治疗中进一步研究。
