Kazmi Syed Shabi Ul Hassan, Tayyab Muhammad, Pastorino Paolo, Barcelò Damià, Yaseen Zaher Mundher, Grossart Hans-Peter, Khan Zulqarnain Haider, Li Gang
Key Laboratory of Urban Environment and Health, Ningbo Urban Environment Observation and Research Station, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, PR China; Zhejiang Key Laboratory of Urban Environmental Processes and Pollution Control, CAS Haixi Industrial Technology Innovation Center in Beilun, Ningbo 315830, PR China.
Institute of Marine Sciences and Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou 515063, PR China.
J Hazard Mater. 2024 Jul 5;472:134574. doi: 10.1016/j.jhazmat.2024.134574. Epub 2024 May 11.
The pervasive and steadily increasing presence of microplastics/nanoplastics (MPs/NPs) in aquatic environments has raised significant concerns regarding their potential adverse effects on aquatic organisms and their integration into trophic dynamics. This emerging issue has garnered the attention of (eco)toxicologists, promoting the utilization of toxicotranscriptomics to unravel the responses of aquatic organisms not only to MPs/NPs but also to a wide spectrum of environmental pollutants. This review aims to systematically explore the broad repertoire of predicted molecular responses by aquatic organisms, providing valuable intuitions into complex interactions between plastic pollutants and aquatic biota. By synthesizing the latest literature, present analysis sheds light on transcriptomic signatures like gene expression, interconnected pathways and overall molecular mechanisms influenced by various plasticizers. Harmful effects of these contaminants on key genes/protein transcripts associated with crucial pathways lead to abnormal immune response, metabolic response, neural response, apoptosis and DNA damage, growth, development, reproductive abnormalities, detoxification, and oxidative stress in aquatic organisms. However, unique challenge lies in enhancing the fingerprint of MPs/NPs, presenting complicated enigma that requires decoding their specific impact at molecular levels. The exploration endeavors, not only to consolidate existing knowledge, but also to identify critical gaps in understanding, push forward the frontiers of knowledge about transcriptomic signatures of plastic contaminants. Moreover, this appraisal emphasizes the imperative to monitor and mitigate the contamination of commercially important aquatic species by MPs/NPs, highlighting the pivotal role that regulatory frameworks must play in protecting all aquatic ecosystems. This commitment aligns with the broader goal of ensuring the sustainability of aquatic resources and the resilience of ecosystems facing the growing threat of plastic pollutants.
微塑料/纳米塑料（MPs/NPs）在水生环境中普遍且持续增加的存在，引发了人们对其对水生生物潜在不利影响以及它们融入营养动态的重大担忧。这个新出现的问题已经引起了（生态）毒理学家的关注，推动了毒理转录组学的应用，以揭示水生生物不仅对MPs/NPs而且对广泛的环境污染物的反应。本综述旨在系统地探索水生生物预测的分子反应的广泛范围，为塑料污染物与水生生物群之间的复杂相互作用提供有价值的见解。通过综合最新文献，目前的分析揭示了转录组特征，如基因表达、相互关联的途径以及受各种增塑剂影响的整体分子机制。这些污染物对与关键途径相关的关键基因/蛋白质转录本的有害影响，导致水生生物出现异常的免疫反应、代谢反应、神经反应、细胞凋亡和DNA损伤、生长、发育、生殖异常、解毒和氧化应激。然而，独特的挑战在于增强MPs/NPs的特征，呈现出复杂的谜团，需要在分子水平上解读它们的具体影响。这项探索不仅致力于巩固现有知识，还旨在识别理解上的关键差距，推动关于塑料污染物转录组特征的知识前沿。此外，这一评估强调了监测和减轻MPs/NPs对商业上重要的水生物种污染的必要性，突出了监管框架在保护所有水生生态系统中必须发挥的关键作用。这一承诺与确保水生资源可持续性以及面对塑料污染物日益增长威胁的生态系统恢复力的更广泛目标相一致。
