Center of Gallstone Disease, Shanghai East Hospital, Tongji University School of Medicine, and Institution of Gallstone Disease, Tongji University School of Medicine, Shanghai, China.
Center of Gallstone Disease, Shanghai East Hospital, Tongji University School of Medicine, and Institution of Gallstone Disease, Tongji University School of Medicine, Shanghai, China; State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, China; Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Center for Global Health, Nanjing Medical University, Nanjing, Jiangsu, China.
Biochem Biophys Res Commun. 2024 Jul 30;719:150088. doi: 10.1016/j.bbrc.2024.150088. Epub 2024 May 8.
Berberine (BBR) is a traditional Chinese herb with broad antimicrobial activity. Gut microbiota plays an important role in the metabolism of bile acids and cholesterol. Our study investigated the effects of BBR on alleviating cholesterol and bile acid metabolism disorders induced by high cholesterol diet in mice. Adult male C57BL/6J mice fed with high cholesterol diet (HC) containing 1.25 % cholesterol (HC group) or fed with chow diet containing 0.02 % cholesterol (Chow group) served as controls. BBR50 and BBR100 group mice were fed with HC, and oral BBR daily at doses of 50 or 100 mg/kg respectively for 8 weeks. The results showed that BBR could reshape the homeostasis and composition of gut microbiota. The abundance of Clostridium genera was significantly inhibited by BBR, which resulted in a significant reduction of secondary bile acids within the enterohepatic circulation and a significant lower hydrophobic index of bile acids. The absorption of cholesterol in intestine, the deposition of cholesterol in liver and the excretion of cholesterol in biliary tract were significantly inhibited by BBR, which promoted the unsaturation of cholesterol in bile. These findings suggest the potential utility of BBR as a functional food to alleviate the negative effects of high cholesterol diet.
小檗碱（BBR）是一种具有广泛抗菌活性的传统中药。肠道微生物群在胆汁酸和胆固醇代谢中起着重要作用。本研究探讨了 BBR 对缓解高胆固醇饮食诱导的小鼠胆固醇和胆汁酸代谢紊乱的作用。成年雄性 C57BL/6J 小鼠喂食含 1.25%胆固醇的高胆固醇饮食（HC 组）或喂食含 0.02%胆固醇的标准饮食（Chow 组）作为对照。BBR50 和 BBR100 组小鼠喂食 HC，分别以 50 或 100mg/kg 的剂量每天口服 BBR 连续 8 周。结果表明，BBR 可以重塑肠道微生物群的内稳态和组成。BBR 显著抑制梭菌属的丰度，导致肠肝循环中次级胆汁酸显著减少，胆汁酸的疏水性指数显著降低。BBR 显著抑制肠道胆固醇吸收、肝脏胆固醇沉积和胆道胆固醇排泄，促进胆汁中胆固醇的不饱和。这些发现表明 BBR 作为一种功能性食品具有缓解高胆固醇饮食负面影响的潜力。
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