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小檗碱及其衍生物：对心肌血管内皮损伤的作用机制——综述

Berberine and its derivatives: mechanisms of action in myocardial vascular endothelial injury - a review.

作者信息

Zhang Wenhui, Guo Siyi, Dou Jinjin, Zhang Xiwu, Shi Fan, Zhang Chun, Zhang Huxiao, Lan Xiaodong, Su Yi

机构信息

Graduate School, Heilongjiang University of Traditional Chinese Medicine, Harbin, China.

First Clinical Medical School, Shandong University of Traditional Chinese Medicine, Jinan, China.

出版信息

Front Pharmacol. 2025 Mar 4;16:1543697. doi: 10.3389/fphar.2025.1543697. eCollection 2025.

DOI:10.3389/fphar.2025.1543697
PMID:40103596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11914797/
Abstract

Myocardial vascular endothelial injury serves as a crucial inducer of cardiovascular diseases. Mechanisms such as endoplasmic reticulum stress, apoptosis, inflammation, oxidative stress, autophagy, platelet dysfunction, and gut microbiota imbalance are intimately linked to this condition. Berberine and its derivatives have demonstrated potential in modulating these mechanisms. This article reviews the pathogenesis of endothelial injury in myocardial vessels, the pharmacological effects of berberine and its derivatives, particularly their interactions with targets implicated in vascular endothelial injury. Furthermore, it discusses clinical applications, methods to enhance bioavailability, and toxicity concerns, aiming to lay a foundation for the development of BBR as a therapeutic agent for cardiovascular diseases.

摘要

心肌血管内皮损伤是心血管疾病的关键诱因。内质网应激、细胞凋亡、炎症、氧化应激、自噬、血小板功能障碍和肠道微生物群失衡等机制与这种情况密切相关。黄连素及其衍生物已显示出调节这些机制的潜力。本文综述了心肌血管内皮损伤的发病机制、黄连素及其衍生物的药理作用，特别是它们与血管内皮损伤相关靶点的相互作用。此外，还讨论了临床应用、提高生物利用度的方法以及毒性问题，旨在为黄连素作为心血管疾病治疗药物的开发奠定基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/b2711c8271af/fphar-16-1543697-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/9becec63b824/fphar-16-1543697-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/5122be6066c3/fphar-16-1543697-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/0788eabd3cd0/fphar-16-1543697-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/b05767e578a4/fphar-16-1543697-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/5cc95c24ed3e/fphar-16-1543697-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/773aa33fe0fb/fphar-16-1543697-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/9a407a260b54/fphar-16-1543697-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/b2711c8271af/fphar-16-1543697-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/9becec63b824/fphar-16-1543697-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/5122be6066c3/fphar-16-1543697-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/0788eabd3cd0/fphar-16-1543697-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/b05767e578a4/fphar-16-1543697-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/5cc95c24ed3e/fphar-16-1543697-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/773aa33fe0fb/fphar-16-1543697-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/9a407a260b54/fphar-16-1543697-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0946/11914797/b2711c8271af/fphar-16-1543697-g008.jpg

相似文献

[1]
Berberine and its derivatives: mechanisms of action in myocardial vascular endothelial injury - a review.

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[2]
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[3]
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[4]
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[6]
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[8]
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[10]
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引用本文的文献

[1]
Natural products for intervertebral disc degeneration: mechanistic insights and therapeutic potentials.

Front Pharmacol. 2025-7-25

[2]
Berberine nanoemulsion attenuates bisphenol A-induced metabolic impairment through NF-κB signaling in the liver of rat.

Toxicol Rep. 2025-6-17

本文引用的文献

[1]
The PINK1/Parkin signaling pathway-mediated mitophagy: a forgotten protagonist in myocardial ischemia/reperfusion injury.

Pharmacol Res. 2024-11

[2]
Berberine and magnolol exert cooperative effects on ulcerative colitis in mice by self-assembling into carrier-free nanostructures.

J Nanobiotechnology. 2024-9-4

[3]
Comparative Effects of and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obese Patients: A Randomized Study.

Nutrients. 2024-7-16

[4]
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction.

Angiogenesis. 2024-11

[5]
Berberine ameliorates vascular dysfunction by downregulating TMAO-endoplasmic reticulum stress pathway via gut microbiota in hypertension.

Microbiol Res. 2024-10

[6]
TMAO Impairs Mouse Aortic Vasodilation by Inhibiting TRPV4 Channels in Endothelial Cells.

J Cardiovasc Transl Res. 2024-12

[7]
Berberine ameliorates chronic intermittent hypoxia-induced cardiac remodelling by preserving mitochondrial function, role of SIRT6 signalling.

J Cell Mol Med. 2024-6

[8]
The short-chain fatty acid propionate prevents ox-LDL-induced coronary microvascular dysfunction by alleviating endoplasmic reticulum stress in HCMECs.

PLoS One. 2024

[9]
Berberine alleviates cholesterol and bile acid metabolism disorders induced by high cholesterol diet in mice.

Biochem Biophys Res Commun. 2024-7-30

[10]
Berberine inhibits excessive autophagy and protects myocardium against ischemia/reperfusion injury via the RhoE/AMPK pathway.

Int J Mol Med. 2024-5

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