Komine S, Nakanishi K, Anzai T, Yoshimoto A
Cell Biochem Funct. 1985 Jan;3(1):33-9. doi: 10.1002/cbf.290030108.
In the early stage of mammary gland involution, biochemically detectable lysosomal damage occurs. The mechanism(s) underlying this damage is not well understood. We found that alpha-lactalbumin from mouse milk induced the release of enzymes from the lysosomes of mouse mammary epithelial cells in vitro, and this induction also occurred with bovine alpha-lactalbumin. This enzyme release was accelerated by the addition of whey proteins with a molecular weight of 50 000 to 60 000. We also found that the lysosomal membrane of mammary epithelial cells had a strong affinity for alpha-lactalbumin.
在乳腺退化的早期，会出现生物化学可检测到的溶酶体损伤。这种损伤的潜在机制尚不清楚。我们发现，来自小鼠乳汁的α-乳白蛋白在体外可诱导小鼠乳腺上皮细胞溶酶体释放酶，牛α-乳白蛋白也会出现这种诱导作用。添加分子量为50000至60000的乳清蛋白可加速这种酶的释放。我们还发现，乳腺上皮细胞的溶酶体膜对α-乳白蛋白具有很强的亲和力。
