减重手术对循环鸢尾素水平的影响：一项系统评价和荟萃分析。
Impact of bariatric surgery on circulating irisin levels: a systematic review and meta‑analysis.
作者信息
Jamialahamdi Tannaz, Mirhadi Elaheh, Almahmeed Wael, Eid Ali H, Al-Rasadi Khalid, Nguyen Ninh T, Gadde Kishore M, Sahebkar Amirhossein
机构信息
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Updates Surg. 2024 Dec;76(8):2745-2754. doi: 10.1007/s13304-024-01866-8. Epub 2024 May 14.
This systematic review and meta-analysis evaluated changes in circulating irisin levels after bariatric surgery. A systematic search was performed across Embase, Scopus, PubMed, and Web of Science for this study. The meta-analysis was conducted using Comprehensive Meta-Analysis (CMA) V4 software. The overall effect size was depicted through a random-effects meta-analysis and the leave-one-out method. The meta-analysis, which included 13 studies with a total of 407 participants, showed a statistically non-significant reduction in circulating irisin levels following bariatric surgery (SMD: - 0.089, 95% CI - 0.281, 0.102, 95% PI: - 0.790, 0.611, p = 0.360; I:70.56). Our research found no significant change in irisin levels after bariatric surgery. Moreover, these findings were not associated with the type of surgery or the duration of follow-up.
本系统评价和荟萃分析评估了减肥手术后循环鸢尾素水平的变化。本研究在Embase、Scopus、PubMed和Web of Science数据库中进行了系统检索。荟萃分析使用综合荟萃分析（CMA）V4软件进行。总体效应量通过随机效应荟萃分析和留一法进行描述。该荟萃分析纳入了13项研究，共407名参与者，结果显示减肥手术后循环鸢尾素水平有统计学上无显著意义的降低（标准化均数差：-0.089，95%置信区间-0.281，0.102，95%预测区间：-0.790，0.611，p = 0.360；I²：70.56）。我们的研究发现减肥手术后鸢尾素水平无显著变化。此外，这些发现与手术类型或随访时间无关。
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