Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY, USA.
Mult Scler Relat Disord. 2024 Jul;87:105668. doi: 10.1016/j.msard.2024.105668. Epub 2024 May 6.
The choroid plexus (CP), located within the ventricles of the brain and the primary producer of cerebrospinal fluid, has been shown to be enlarged in patients with multiple sclerosis (MS) and linked to periventricular remyelination failure. Atrophied T2-lesion volume (aT2-LV), a promising neurodegenerative imaging marker in progressive MS (PMS), reflects the volume of periventricular lesions subsumed into cerebrospinal fluid over the follow-up.
In a cohort of 143 people with relapsing-remitting MS (RRMS) and 53 with PMS, we used 3T magnetic resonance imaging (MRI) to quantify CP volume (CPV) at baseline and aT2-LV over an average of 5.4 years of follow-up. Partial correlations, adjusting for age and sex, and linear regression analyses were used to assess the relationships between imaging measures.
In both cohorts, CPV was associated with aT2-LV in both the RRMS group (r = 0.329, p < 0.001) as well as the PMS group (r = 0.522, p < 0.001). In regression analyses predicting aT2-LV, ventricular volume (final adjusted R2 = 0.407, p < 0.001) explained additional variance beyond age, sex, and T2-lesion volume in the RRMS group while CPV (final adjusted R2 = 0.446, p = 0.009) was retained in the PMS group.
Findings from this study suggest that the CP enlargement is associated with future neurodegeneration, with a particularly relevant role in PMS.
脉络丛（CP）位于脑室内，是脑脊液的主要产生者，已被证明在多发性硬化症（MS）患者中增大，并与脑室周围髓鞘再生失败有关。萎缩性 T2 病变体积（aT2-LV）是进展型多发性硬化症（PMS）中一种有前途的神经退行性成像标志物，反映了随访期间脑脊液中包含的脑室周围病变的体积。
在 143 例复发缓解型多发性硬化症（RRMS）和 53 例 PMS 患者的队列中，我们使用 3T 磁共振成像（MRI）在基线时定量 CP 体积（CPV），并在平均 5.4 年的随访中测量 aT2-LV。使用偏相关分析，调整年龄和性别，并进行线性回归分析，以评估影像学测量之间的关系。
在两个队列中，CPV 与 RRMS 组（r = 0.329，p < 0.001）和 PMS 组（r = 0.522，p < 0.001）的 aT2-LV 均相关。在预测 aT2-LV 的回归分析中，脑室体积（最终调整 R2 = 0.407，p < 0.001）在 RRMS 组中解释了年龄、性别和 T2 病变体积之外的额外方差，而 CPV（最终调整 R2 = 0.446，p = 0.009）在 PMS 组中保留。
本研究的结果表明 CP 增大与未来的神经退行性变有关，在 PMS 中具有特别重要的作用。
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