Department of Radiation Oncology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.
School of Medicine, Tzu Chi University, Hualien, Taiwan.
Hum Vaccin Immunother. 2024 Dec 31;20(1):2350093. doi: 10.1080/21645515.2024.2350093. Epub 2024 May 14.
Colorectal cancer (CRC) long-term survivor is a rapid enlarging group. However, the effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPSV23) on this group is unknown. This nationwide population-based study in Taiwan was designed to examine the effect of PPSV23 on incidence rate ratio (IRR) of pneumonia hospitalization, cumulative incidence, and overall survival rate for these long-term CRC survivors. This cohort study was based on the Taiwan Cancer Registry and Taiwan National Health Insurance Research Database from 2000-2017. After individual exact matching to covariates with 1:1 ratio, there were a total of 1,355 vaccinated and 1,355 unvaccinated survivors. After adjusted by multivariate Poisson regression model, vaccinated group had a non-significantly lower pneumonia hospitalization risk than unvaccinated, with an adjusted IRR of 0.879 ( = .391). Besides, vaccinated group had both lower cumulative incidence rate and higher overall survival time than unvaccinated.
结直肠癌（CRC）长期幸存者是一个迅速扩大的群体。然而，23 价肺炎球菌多糖疫苗（PPSV23）对该群体的有效性尚不清楚。这项在台湾进行的全国性基于人群的研究旨在探讨 PPSV23 对肺炎住院发病率比（IRR）、累积发病率和这些长期 CRC 幸存者的总生存率的影响。该队列研究基于 2000 年至 2017 年的台湾癌症登记处和台湾全民健康保险研究数据库。在以 1:1 的比例对协变量进行个体精确匹配后，共有 1355 名接种疫苗和 1355 名未接种疫苗的幸存者。经过多变量泊松回归模型调整后，接种组肺炎住院风险较未接种组非显著降低，调整后的发病率比（IRR）为 0.879（ = .391）。此外，接种组的累积发病率较低，总生存时间较长。
