Servant Guy, Kenakin Terry
dsm-firmenich, 10636 Scripps Summit Court #201, San Diego, CA 92131, USA.
Department of Pharmacology, University of North Carolina School of Medicine, 120 Mason Farm Rd., 4042 Genetic Medicine CB #7365, Chapel Hill, NC 27599, USA.
Pharmacol Res. 2024 Jun;204:107211. doi: 10.1016/j.phrs.2024.107211. Epub 2024 May 12.
Several non-caloric sweeteners exhibit a delay in sweetness onset and a sweetness linger after sampling. These temporal properties are thought to be the result of non-specific interactions with cell membranes and proteins in the oral cavity. Data and analysis presented in this report also support the potential involvement of receptor affinity and binding kinetics to this phenomenon. In general, affected sweeteners exhibit distinctly higher binding affinity compared to carbohydrate sweeteners, which do not have temporal issues. In addition, binding kinetic simulations illustrate much slower receptor binding association and dissociation kinetics for a set of non-caloric sweeteners presenting temporal issues, in comparison to carbohydrate sweeteners. So, the higher affinity of some non-caloric sweeteners, dictating lower use levels, and affecting binding kinetics, could contribute to their delay and linger in sweetness perception. Simple pharmacology principles could explain, at least in part, some of the temporal issues of sweeteners.
几种非热量甜味剂在品尝后会出现甜味起始延迟和甜味残留的现象。这些时间特性被认为是与口腔中的细胞膜和蛋白质发生非特异性相互作用的结果。本报告中呈现的数据和分析也支持受体亲和力和结合动力学可能参与了这一现象。一般来说，与不存在时间问题的碳水化合物甜味剂相比，受影响的甜味剂表现出明显更高的结合亲和力。此外，结合动力学模拟表明，与碳水化合物甜味剂相比，一组存在时间问题的非热量甜味剂的受体结合缔合和解离动力学要慢得多。因此，一些非热量甜味剂的较高亲和力决定了其较低的使用水平，并影响结合动力学，这可能导致它们在甜味感知上的延迟和残留。简单的药理学原理至少可以部分解释甜味剂的一些时间问题。
