Key Laboratory of Functional Proteomics of Guangdong Province, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Autophagy. 2024 Sep;20(9):2112-2113. doi: 10.1080/15548627.2024.2355072. Epub 2024 May 22.
Hematopoietic stem cells (HSC) emerge from hemogenic endothelial cells (HEC) in the aorta-gonad-mesonephros (AGM) region of embryos, which go through the pre-HSC process. Various intrinsic and extrinsic factors are involved in this process. We recently discovered that the existence of distinct macroautophagic/autophagic statuses in hematopoietic precursors is related to the hematopoietic potential of pre-HSCs and the depletion of the (autophagy related 5) gene specifically in endothelial cells impaired in the transition of endothelial to pre-HSCs, by hampering the autophagic process, likely via the NCL (nucleolin) pathway. Atg5: autophagy related 5; EGFP: enhanced green fluorescent protein; EHT: endothelial-to-hematopoietic transition; HEC: hemogenic endothelial cell; HSC: hematopoietic stem cell; NCL: nucleolin; RFP: red fluorescent protein.
造血干细胞 (HSC) 来源于胚胎主动脉-性腺-中肾 (AGM) 区域的造血内皮细胞 (HEC)，经历前 HSC 过程。多种内在和外在因素参与了这一过程。我们最近发现，造血前体细胞中存在不同的巨自噬/自噬状态与前 HSCs 的造血潜能有关，并且内皮细胞中 （自噬相关 5 基因）的缺失特异性地干扰了内皮细胞向前 HSCs 的过渡，通过阻碍自噬过程，可能通过 NCL（核仁素）途径。Atg5：自噬相关 5；EGFP：增强型绿色荧光蛋白；EHT：内皮细胞向造血细胞过渡；HEC：造血内皮细胞；HSC：造血干细胞；NCL：核仁素；RFP：红色荧光蛋白。
