Madere Tyler C, Mendez Jennifer B, Nordmeyer Sarah T, Heidel R Eric, Hamilton Leslie A
Internal Medicine, JPS Health Network, Fort Worth, Texas.
Medication Use Specialist, University of Tennessee Medical Center, Knoxville, Tennessee.
Hosp Pharm. 2016 Mar;51(3):230-236. doi: 10.1310/hpj5103-230. Epub 2016 Mar 1.
The objective of this study is to evaluate the effect of intravenous acetaminophen on length of stay (LOS) in abdominal surgery patients.
This retrospective, cohort chart review evaluated patients who underwent colon resection or pancreaticoduodenectomy between January 1, 2010 and August 31, 2013. The primary outcome is postoperative LOS. Secondary outcomes include opioid use, pain scores, and naloxone or laxative use. Patients who received intravenous acetaminophen were compared to patients who did not.
A total of 329 patients were included, with 269 in the non-acetaminophen group compared to 60 patients in the acetaminophen group. There was no difference in postoperative LOS (9.2 s vs 9.1 days; = .90). Postoperative LOS was also similar when controlling for surgery type. The acetaminophen group had reduced opioid consumption in the first 24 hours postoperatively ( = .02). However, pain scores were higher in the acetaminophen group, both in the first 24 hours ( = .007) and throughout the hospital stay ( < .001). Other clinical outcomes were similar between groups.
Intravenous acetaminophen was not associated with a decreased postoperative LOS at our institution.
本研究的目的是评估静脉注射对乙酰氨基酚对腹部手术患者住院时间（LOS）的影响。
这项回顾性队列图表审查评估了2010年1月1日至2013年8月31日期间接受结肠切除术或胰十二指肠切除术的患者。主要结局是术后住院时间。次要结局包括阿片类药物使用、疼痛评分以及纳洛酮或泻药使用情况。将接受静脉注射对乙酰氨基酚的患者与未接受的患者进行比较。
共纳入329例患者，非对乙酰氨基酚组269例，对乙酰氨基酚组60例。术后住院时间无差异（9.2天对9.1天；P = 0.90）。在控制手术类型时，术后住院时间也相似。对乙酰氨基酚组术后24小时内阿片类药物消耗量减少（P = 0.02）。然而，对乙酰氨基酚组的疼痛评分更高，在术后24小时内（P = 0.007）以及整个住院期间（P < 0.001）均如此。两组之间的其他临床结局相似。
在我们机构，静脉注射对乙酰氨基酚与术后住院时间缩短无关。
