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采用墨西哥吸烟与 vaping 模型(SAVM)取消对电子尼古丁输送系统的禁令可能产生的影响。

The potential impact of removing a ban on electronic nicotine delivery systems using the Mexico smoking and vaping model (SAVM).

作者信息

Sánchez-Romero Luz María, Li Yameng, Zavala-Arciniega Luis, Gallegos-Carrillo Katia, Thrasher James F, Meza Rafael, Levy David T

机构信息

Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC. United States of America.

Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America.

出版信息

medRxiv. 2024 Apr 30:2024.04.28.24306511. doi: 10.1101/2024.04.28.24306511.

Abstract

OBJECTIVE

To develop the Mexico Smoking and Vaping Model (Mexico SAVM) to estimate cigarette and electronic nicotine delivery systems (ENDS) prevalence and the public health impact of legalizing ENDS use.

METHODS

SAVM, a cohort-based discrete-time simulation model, compares two scenarios. The estimates smoking prevalence and associated mortality outcomes under the current policy of an ENDS ban, using Mexico-specific population projections, death rates, life expectancy, and smoking and e-cigarette prevalence. projects smoking and vaping prevalence under a hypothetical scenario where ENDS use is allowed. The impact of legalizing ENDS use is estimated as the difference in smoking- and vaping-attributable deaths (SVADs) and life-years lost (LYLs) between the ENDS-Restricted and Unrestricted scenarios.

RESULTS

Compared to a national ENDS ban, The Mexico SAVM projects that legalizing ENDS use could decrease smoking prevalence by 40.1% in males and 30.9% in females by 2049 compared to continuing the national ENDS ban. This reduction in prevalence would save 2.9 (2.5 males and 0.4 females) million life-years and avert almost 106 (91.0 males and 15.5 females) thousand deaths between 2025 and 2049. Public health gains decline by 43% to 59,748 SVADs averted when the switching rate is reduced by half and by 24.3% (92,806 SVADs averted) with a 25% ENDS risk level from that of cigarettes but increased by 24.3% (121,375 SVADs averted) with the 5% ENDS risk.

CONCLUSIONS

Mexico SAVM suggests that greater access to ENDS and a more permissive ENDS regulation, simultaneous with strong cigarette policies, would reduce smoking prevalence and decrease smoking-related mortality. The unanticipated effects of an ENDS ban merit closer scrutiny, with further consideration of how specific ENDS restrictions may maximize public health benefits.

摘要

目的

开发墨西哥吸烟与电子烟模型(Mexico SAVM),以估计香烟和电子尼古丁传送系统(ENDS)的流行情况以及ENDS使用合法化对公共卫生的影响。

方法

SAVM是一个基于队列的离散时间模拟模型,比较两种情景。一种情景使用墨西哥特定的人口预测、死亡率、预期寿命以及吸烟和电子烟流行率,在当前ENDS禁令政策下估计吸烟流行率及相关死亡结果。另一种情景预测在允许使用ENDS的假设情况下的吸烟和电子烟流行率。ENDS使用合法化的影响通过ENDS限制和非限制情景之间吸烟和电子烟归因死亡(SVADs)及生命年损失(LYLs)的差异来估计。

结果

与全国性的ENDS禁令相比,墨西哥SAVM预测,到2049年,与继续实施全国性ENDS禁令相比,ENDS使用合法化可使男性吸烟流行率降低40.1%,女性降低30.9%。这种流行率的降低将在2025年至2049年期间挽救290万(男性250万,女性40万)生命年,并避免近10.6万(男性9.1万,女性1.55万)例死亡。当转换率减半时,公共卫生收益下降43%,降至避免59748例SVADs;当ENDS风险水平比香烟低25%时,公共卫生收益下降24.3%(避免92806例SVADs);而当ENDS风险为5%时,公共卫生收益增加24.3%(避免121375例SVADs)。

结论

墨西哥SAVM表明,在实施强有力的香烟政策的同时,增加ENDS的可及性和实行更宽松的ENDS监管,将降低吸烟流行率并减少与吸烟相关的死亡率。ENDS禁令的意外影响值得更密切的审视,需进一步考虑特定的ENDS限制如何能使公共卫生效益最大化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f951/11092684/50d59e39c80a/nihpp-2024.04.28.24306511v1-f0001.jpg

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