Sánchez-Romero Luz María, Li Yameng, Zavala-Arciniega Luis, Gallegos-Carrillo Katia, Thrasher James F, Meza Rafael, Levy David T
Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC. United States of America.
Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, United States of America.
medRxiv. 2024 Apr 30:2024.04.28.24306511. doi: 10.1101/2024.04.28.24306511.
To develop the Mexico Smoking and Vaping Model (Mexico SAVM) to estimate cigarette and electronic nicotine delivery systems (ENDS) prevalence and the public health impact of legalizing ENDS use.
SAVM, a cohort-based discrete-time simulation model, compares two scenarios. The estimates smoking prevalence and associated mortality outcomes under the current policy of an ENDS ban, using Mexico-specific population projections, death rates, life expectancy, and smoking and e-cigarette prevalence. projects smoking and vaping prevalence under a hypothetical scenario where ENDS use is allowed. The impact of legalizing ENDS use is estimated as the difference in smoking- and vaping-attributable deaths (SVADs) and life-years lost (LYLs) between the ENDS-Restricted and Unrestricted scenarios.
Compared to a national ENDS ban, The Mexico SAVM projects that legalizing ENDS use could decrease smoking prevalence by 40.1% in males and 30.9% in females by 2049 compared to continuing the national ENDS ban. This reduction in prevalence would save 2.9 (2.5 males and 0.4 females) million life-years and avert almost 106 (91.0 males and 15.5 females) thousand deaths between 2025 and 2049. Public health gains decline by 43% to 59,748 SVADs averted when the switching rate is reduced by half and by 24.3% (92,806 SVADs averted) with a 25% ENDS risk level from that of cigarettes but increased by 24.3% (121,375 SVADs averted) with the 5% ENDS risk.
Mexico SAVM suggests that greater access to ENDS and a more permissive ENDS regulation, simultaneous with strong cigarette policies, would reduce smoking prevalence and decrease smoking-related mortality. The unanticipated effects of an ENDS ban merit closer scrutiny, with further consideration of how specific ENDS restrictions may maximize public health benefits.
开发墨西哥吸烟与电子烟模型(Mexico SAVM),以估计香烟和电子尼古丁传送系统(ENDS)的流行情况以及ENDS使用合法化对公共卫生的影响。
SAVM是一个基于队列的离散时间模拟模型,比较两种情景。一种情景使用墨西哥特定的人口预测、死亡率、预期寿命以及吸烟和电子烟流行率,在当前ENDS禁令政策下估计吸烟流行率及相关死亡结果。另一种情景预测在允许使用ENDS的假设情况下的吸烟和电子烟流行率。ENDS使用合法化的影响通过ENDS限制和非限制情景之间吸烟和电子烟归因死亡(SVADs)及生命年损失(LYLs)的差异来估计。
与全国性的ENDS禁令相比,墨西哥SAVM预测,到2049年,与继续实施全国性ENDS禁令相比,ENDS使用合法化可使男性吸烟流行率降低40.1%,女性降低30.9%。这种流行率的降低将在2025年至2049年期间挽救290万(男性250万,女性40万)生命年,并避免近10.6万(男性9.1万,女性1.55万)例死亡。当转换率减半时,公共卫生收益下降43%,降至避免59748例SVADs;当ENDS风险水平比香烟低25%时,公共卫生收益下降24.3%(避免92806例SVADs);而当ENDS风险为5%时,公共卫生收益增加24.3%(避免121375例SVADs)。
墨西哥SAVM表明,在实施强有力的香烟政策的同时,增加ENDS的可及性和实行更宽松的ENDS监管,将降低吸烟流行率并减少与吸烟相关的死亡率。ENDS禁令的意外影响值得更密切的审视,需进一步考虑特定的ENDS限制如何能使公共卫生效益最大化。