Holt P G, Leivers S
Aust J Exp Biol Med Sci. 1985 Feb;63 ( Pt 1):33-9. doi: 10.1038/icb.1985.4.
Previous studies on the antigen-presenting activity of alveolar macrophages (AM) have been restricted to the use of in vitro assay systems, and have generally shown suppression of T cell activation by these macrophages. The present study exploits the rapid adaptability of AM to changes in oxygen tension, which facilitates their transfer to other tissues in a functional state. Employing this rationale, antigen-pulsed AM were shown to trigger T cell-dependent immune responses following subcutaneous or intraperitoneal inoculation, while suppressing similar responses in tissue culture.
以往关于肺泡巨噬细胞（AM）抗原呈递活性的研究仅限于使用体外检测系统，并且总体上显示这些巨噬细胞会抑制T细胞活化。本研究利用了AM对氧张力变化的快速适应性，这有助于它们以功能状态转移到其他组织。基于这一原理，经抗原脉冲处理的AM在皮下或腹腔接种后可触发T细胞依赖性免疫反应，而在组织培养中则会抑制类似反应。
