Jendrichovsky Peter, Lee Hey-Kyoung, Kanold Patrick O
Department of Biomedical Engineering, Johns Hopkins University School of Medicine; Baltimore, USA.
Department of Neuroscience, Johns Hopkins University School of Medicine; Baltimore, USA.
bioRxiv. 2024 May 3:2024.05.02.592252. doi: 10.1101/2024.05.02.592252.
Plastic changes in the brain are primarily limited to early postnatal periods. Recovery of adult brain plasticity is critical for the effective development of therapies. A brief (1-2 week) duration of visual deprivation (dark exposure, DE) in adult mice can trigger functional plasticity of thalamocortical and intracortical circuits in the primary auditory cortex suggesting improved sound processing. We tested if DE enhances the ability of adult mice to detect sounds. We trained and continuously evaluated the behavioral performance of mice in control and DE conditions using automated home-cage training. Consistent with age-related peripheral hearing loss present in C57BL/6J mice, we observed decreased performance for high-frequency sounds with age, which was reduced by DE. In CBA mice with preserved peripheral hearing, we also found that DE enhanced auditory performance in low and mid frequencies over time compared to the control.
大脑中的可塑性变化主要局限于出生后的早期阶段。恢复成人大脑的可塑性对于有效开发治疗方法至关重要。成年小鼠短暂（1-2周）的视觉剥夺（黑暗暴露，DE）可触发初级听觉皮层中丘脑皮质和皮质内回路的功能可塑性，表明声音处理能力得到改善。我们测试了DE是否能增强成年小鼠检测声音的能力。我们使用自动笼内训练对处于对照和DE条件下的小鼠的行为表现进行训练并持续评估。与C57BL/6J小鼠中存在的与年龄相关的外周听力损失一致，我们观察到随着年龄的增长，高频声音的表现下降，而DE可使其降低。在具有保留的外周听力的CBA小鼠中，我们还发现与对照相比，随着时间的推移，DE增强了低频和中频的听觉表现。
