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参与肿瘤代谢调节的嘌呤体:当前进展与潜在应用靶点

Purinosomes involved in the regulation of tumor metabolism: current progress and potential application targets.

作者信息

Xie Jiaqi, Liu Jiaqi, Chen Xiehui, Zeng Changchun

机构信息

Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou, China.

Department of General Medicine, Shenzhen Longhua District Central Hospital, Shenzhen, China.

出版信息

Front Oncol. 2024 Apr 26;14:1333822. doi: 10.3389/fonc.2024.1333822. eCollection 2024.

Abstract

The core of tumor cell metabolism is the management of energy metabolism due to the extremely high energy requirements of tumor cells. The purine nucleotide synthesis pathway in cells uses the purinosomes as an essential spatial structural complex. In addition to serving a crucial regulatory role in the emergence and growth of tumors, it contributes to the synthesis and metabolism of purine nucleotides. The significance of purine metabolism in tumor cells is initially addressed in this current article. The role of purinosomes as prospective therapeutic targets is then reviewed, along with a list of the signaling pathways that play in the regulation of tumor metabolism. A thorough comprehension of the function of purinosomes in the control of tumor metabolism can generate fresh suggestions for the creation of innovative cancer treatment methods.

摘要

由于肿瘤细胞对能量的需求极高,肿瘤细胞代谢的核心是能量代谢的管理。细胞中的嘌呤核苷酸合成途径以嘌呤小体作为重要的空间结构复合体。它不仅在肿瘤的发生和生长中起关键调节作用,还参与嘌呤核苷酸的合成与代谢。本文首先阐述了嘌呤代谢在肿瘤细胞中的意义。接着综述了嘌呤小体作为潜在治疗靶点的作用,以及参与肿瘤代谢调控的信号通路列表。深入理解嘌呤小体在肿瘤代谢调控中的功能可为创新癌症治疗方法的开发提供新的思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80bf/11091722/86bf1b20ee50/fonc-14-1333822-g001.jpg

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