颈肌张力障碍中的焦虑理解：一项影像学研究。
Understanding Anxiety in Cervical Dystonia: An Imaging Study.
机构信息
Gardner Family Center For Parkinson's Disease and Movement Disorders, University of Cincinnati, Cincinnati, Ohio, USA.
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
出版信息
Mov Disord Clin Pract. 2024 Aug;11(8):1008-1012. doi: 10.1002/mdc3.14070. Epub 2024 May 15.
BACKGROUND
Anxiety may precede motor symptoms in cervical dystonia (CD) and is associated with an earlier onset of dystonia. Our understanding of anxiety in CD is inadequate.
OBJECTIVE
To investigate brain networks associated with anxiety in CD.
METHODS
Twenty-six subjects with idiopathic CD underwent MRI Brain without contrast. Correlational tractography was derived using Diffusion MRI connectometry. Quantitative Anisotropy (QA) was used in deterministic diffusion fiber tracking. Correlational tractography was then used to correlate QA with State-Trait Anxiety Inventory (STAI) state (STAI-S) and trait (STAI-T) subscales.
RESULTS
Connectometry analysis showed direct correlation between state anxiety and QA in tracts from amygdala to thalamus/ pulvinar bilaterally, and trait anxiety and QA in tracts from amygdala to motor cortex, sensorimotor cortex and parietal association area bilaterally (FDR ≤0.05).
CONCLUSION
Our efforts to map anxiety to brain networks in CD highlight the role of the amygdala in the pathophysiology of anxiety in CD.
背景
焦虑可能先于颈部肌张力障碍（CD）的运动症状出现，并且与肌张力障碍的发病较早有关。我们对 CD 中的焦虑的理解还不够充分。
目的
探讨与 CD 中的焦虑相关的脑网络。
方法
26 名特发性 CD 患者接受了 MRI 脑无对比检查。使用弥散磁共振连接测量法得出关联轨迹。使用定量各向异性（QA）进行确定性弥散纤维追踪。然后使用关联轨迹将 QA 与状态-特质焦虑量表（STAI）的状态（STAI-S）和特质（STAI-T）分量进行相关性分析。
结果
连接测量法分析显示，状态焦虑与双侧杏仁核至丘脑/髓质的 QA 之间存在直接相关性，特质焦虑与双侧杏仁核至运动皮层、感觉运动皮层和顶叶联合区的 QA 之间存在直接相关性（FDR≤0.05）。
结论
我们努力将焦虑映射到 CD 中的脑网络，强调了杏仁核在 CD 中焦虑的病理生理学中的作用。
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