一名患有再生障碍性贫血的儿童存在正常免疫球蛋白的抗体缺陷。
Antibody deficiency with normal immunoglobulins in a child with hypoplastic anemia.
作者信息
Knutsen A P, O'Connor D M
出版信息
Clin Immunol Immunopathol. 1985 Sep;36(3):330-7. doi: 10.1016/0090-1229(85)90053-4.
PMID:3874735
Abstract
We report a young child with hypoplastic anemia and antibody deficiency with normal serum immunoglobulin levels. Studies of antibody responses to bacteriophage phi X 174 revealed an amnestic response but was predominantly limited to IgM. A similar response was observed following booster tetanus toxoid immunization. Analysis of in vitro pokeweed mitogen-induced immunoglobulin synthesis by the patient's B cells suggested an intrinsic B-cell defect.
摘要
我们报告了一名患有发育不全性贫血和抗体缺乏症但血清免疫球蛋白水平正常的幼儿。对噬菌体φX 174的抗体反应研究显示有记忆反应，但主要限于IgM。在破伤风类毒素加强免疫后也观察到类似反应。对患者B细胞体外商陆有丝分裂原诱导的免疫球蛋白合成分析提示存在内在B细胞缺陷。
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