可见光光氧化还原催化的活化烯烃与乙醛酸缩醛和一氧化碳的甲酰化/羧化反应
Visible Light Photoredox-Catalyzed Formyl/Carboxylation of Activated Alkenes with Glyoxylic Acid Acetals and CO.
作者信息
Yang Han, Yao Yang, Yang Qi, Yao Yingming, Sun Jianwei, Sun Song
机构信息
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Scince, Dushu Lake Campus, Soochow University, Suzhou 215123, China.
出版信息
Org Lett. 2024 May 24;26(20):4194-4199. doi: 10.1021/acs.orglett.4c00841. Epub 2024 May 15.
A photoredox-catalyzed sequential α-formyl/carboxylation of alkenes with glyoxylic acid acetals and CO has been developed to afford a range of masked γ-formyl esters in good yields, which could be readily transformed into diverse compounds, such as γ-formyl ester, hemiacetal, and 1,4-diol. This reaction features mild conditions, readily available starting materials, and operational simplicity.
已开发出一种光氧化还原催化的烯烃与乙醛酸缩醛和一氧化碳的顺序α-甲酰基/羧化反应，以高收率得到一系列掩蔽的γ-甲酰基酯，这些酯可很容易地转化为多种化合物，如γ-甲酰基酯、半缩醛和1,4-二醇。该反应具有条件温和、起始原料易得和操作简便的特点。
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