Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, Wuhan, China.
Brain Behav. 2024 May;14(5):e3536. doi: 10.1002/brb3.3536.
To provide thorough insight on the protective role of endothelial glucose transporter 1 (GLUT1) in ischemic stroke.
We comprehensively review the role of endothelial GLUT1 in ischemic stroke by narrating the findings concerning biological characteristics of GLUT1 in brain in depth, summarizing the changes of endothelial GLUT1 expression and activity during ischemic stroke, discussing how GLUT1 achieves its neuroprotective effect via maintaining endothelial function, and identifying some outstanding blind spots in current studies.
Endothelial GLUT1 maintains persistent high glucose and energy requirements of the brain by transporting glucose through the blood-brain barrier, which preserves endothelial function and is beneficial to stroke prognosis.
This review underscores the potential involvement of GLUT1 trafficking, activity modulation, and degradation, and we look forward to more clinical and animal studies to illuminate these mechanisms.
深入了解内皮细胞葡萄糖转运蛋白 1（GLUT1）在缺血性卒中中的保护作用。
通过深入叙述脑内 GLUT1 的生物学特性方面的研究结果，全面综述内皮细胞 GLUT1 在缺血性卒中中的作用，总结缺血性卒中过程中内皮 GLUT1 表达和活性的变化，讨论 GLUT1 通过维持内皮功能来实现其神经保护作用，并指出当前研究中的一些突出盲点。
内皮细胞 GLUT1 通过血脑屏障转运葡萄糖，维持大脑持续的高葡萄糖和能量需求，从而保持内皮功能，有利于卒中预后。
本综述强调了 GLUT1 运输、活性调节和降解的潜在参与，我们期待更多的临床和动物研究来阐明这些机制。
