CNRS, ImmunoConcEpT, UMR 5164, University of Bordeaux, Bordeaux, France.
Biogerontology. 2024 Aug;25(4):739-743. doi: 10.1007/s10522-024-10105-x. Epub 2024 May 15.
The widespread use of the name 'geroscience' in the science of aging is sometimes met with a wary attitude by biogerontologists other than its inventors. Here, we provide an overview of its origin and evolution to assess what exactly it is and to discuss its theoretical and biological relationship to earlier movements of anti-aging medicine and biogerontology more generally. Geroscience posits that targeting aging may offer a cost-effective approach to improve late-life health in humans, and because aging is malleable in model organisms and what regulates this is sufficiently understood, the time is ripe for moving forward to translational and clinical research. The geroscience agenda has rebranded imagery of past traditions, yet the claim that therapies for human aging are ready or within the imminent future is contestable and on brand with tradition, even if biogerontology has made great progress in the past decades.
衰老学领域广泛使用“衰老科学”一词，除了其发明者之外，其他生物老年学家对此持谨慎态度。在这里，我们提供了它的起源和演变的概述，以评估它到底是什么，并讨论它与更早的抗衰老医学和生物老年学运动的理论和生物学关系。衰老科学假设，靶向衰老可能是一种具有成本效益的方法，可以改善人类的晚年健康，而且由于衰老在模式生物中是可塑的，并且调节衰老的机制已经得到充分理解，因此现在是推进转化和临床研究的时机。衰老科学议程重新塑造了过去传统的形象，但声称人类衰老的疗法已经准备好或即将面世，这是有争议的，而且与传统相符，即使生物老年学在过去几十年取得了巨大的进步。
