Zhao Wenjing, Ren Aiqi, Shan Shuhua, Li Zhuoyu, Su Ruijun, Yang Ruipeng, Zhai Feihong, Wu Lihua, Tang Zhaohui, Yang Jieya, Yue Linzhong
Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, China.
Biological Science and Technology Colledge, Taiyuan Normal University, Jinzhong 030619, China.
J Agric Food Chem. 2024 May 29;72(21):12130-12145. doi: 10.1021/acs.jafc.4c00867. Epub 2024 May 15.
Colorectal cancer (CRC) is a common malignant tumor that occurs in the colon. Gut microbiota is a complex ecosystem that plays an important role in the pathogenesis of CRC. Our previous studies showed that the soluble dietary fiber of foxtail millet (FMB-SDF) exhibited significant antitumor activity in vitro. The present study evaluated the anticancer potential of FMB-SDF in the azoxymethane (AOM)- and dextran sodium sulfate (DSS)-induced mouse CRC models. The results showed that FMB-SDF could significantly alleviate colon cancer symptoms in mice. Further, we found that FMB-SDF consumption significantly altered gut microbiota diversity and the overall structure and regulated the abundance of some microorganisms in CRC mice. Meanwhile, KEGG pathway enrichment showed that FMB-SDF can also alleviate the occurrence of colon cancer in mice by regulating certain cancer-related signaling pathways. In conclusion, our findings may provide a novel approach for the prevention and biotherapy of CRC.
结直肠癌（CRC）是一种常见于结肠的恶性肿瘤。肠道微生物群是一个复杂的生态系统，在CRC的发病机制中起重要作用。我们之前的研究表明，谷子可溶性膳食纤维（FMB-SDF）在体外具有显著的抗肿瘤活性。本研究评估了FMB-SDF在氧化偶氮甲烷（AOM）和葡聚糖硫酸钠（DSS）诱导的小鼠CRC模型中的抗癌潜力。结果表明，FMB-SDF可显著减轻小鼠结肠癌症状。此外，我们发现食用FMB-SDF可显著改变CRC小鼠肠道微生物群的多样性和整体结构，并调节某些微生物的丰度。同时，KEGG通路富集表明，FMB-SDF还可通过调节某些癌症相关信号通路减轻小鼠结肠癌的发生。总之，我们的研究结果可能为CRC的预防和生物治疗提供一种新方法。
