Yildiz Technical University, Department of Bioengineering, Istanbul, 34220, Turkiye.
Yildiz Technical University, Department of Molecular Biology and Genetics, Istanbul, 34220, Turkiye.
Macromol Biosci. 2024 Aug;24(8):e2400101. doi: 10.1002/mabi.202400101. Epub 2024 May 23.
Conventional wound dressings fail to provide features that can assist the healing process of chronic wounds. Multifunctional wound dressings address this issue by incorporating attributes including antibacterial and antioxidant activity, and the ability to enhance wound healing. Herein, polyethylene glycol (PEG)-based antibacterial hydrogel sponge dressings are prepared by a rapid and facile gas foaming method based on an acid chloride/alcohol reaction where tannic acid (TA) is included as a reactant to impart antibacterial efficacy as well as to enhance the mechanical properties of the samples. The results reveal that the TA-integrated sponges possess excellent antibacterial properties against both Escherichia coli and Staphylococcus aureus with approximately 6-8 log reduction in the microbial colony count after 6 h, indicating their high potential for management of infection-prone wounds. Compared to the control sample, TA incorporation increases the elastic modulus by twofold. As the samples also exhibit biocompatibility, antioxidant activity, and wound healing capacity, the novel TA-incorporated hydrogels can be an alternative to traditional wound dressings for wounds with low-to-moderate exudate.
传统的伤口敷料无法提供有助于慢性伤口愈合的功能。多功能伤口敷料通过结合抗菌和抗氧化活性以及促进伤口愈合的能力来解决这个问题。本文通过一种快速简便的基于酰氯/醇反应的气体发泡方法制备了基于聚乙二醇（PEG）的抗菌水凝胶海绵敷料，其中包括单宁酸（TA）作为反应物，以赋予抗菌功效并提高样品的机械性能。结果表明，整合了 TA 的海绵对大肠杆菌和金黄色葡萄球菌具有出色的抗菌性能，在 6 小时后微生物菌落数减少了约 6-8 个对数，表明其在管理易感染伤口方面具有巨大的潜力。与对照样品相比，TA 的加入使弹性模量增加了两倍。由于这些样品还表现出生物相容性、抗氧化活性和伤口愈合能力，因此新型 TA 整合水凝胶可作为传统伤口敷料的替代品，用于低至中等渗出液的伤口。
