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增强型体外反搏联合心脏康复治疗非阻塞性冠状动脉疾病伴冠状动脉微血管功能障碍患者的随机对照研究。

A Randomized Controlled Study of Enhanced External Counterpulsation with Cardiac Rehabilitation in Patients with Nonobstructive Coronary Artery Disease and Coronary Microvascular Dysfunction.

机构信息

Bengbu Medical College, Fuyang Peoples Hospital Affiliated to Bengbu Medical College.

出版信息

Int Heart J. 2024 May 31;65(3):380-385. doi: 10.1536/ihj.23-454. Epub 2024 May 15.

Abstract

Treatment with enhanced external counterpulsation (EECP) or cardiac rehabilitation (CR) benefits patients with coronary heart disease; this paper intends to explore the feasibility of EECP combined with CR in patients with nonobstructive coronary heart disease (NOCAD) and coronary microcirculation disorders (CMD).In January 2021-2022 month June our income NOCAD patients as the research object, the line of cardiac magnetic resonance (CMR), myocardial perfusion reserve (MPR) < 2.0 coronary microcirculation disorders (CMD, 80 cases). Random indicator method 80 CMD patients divided into two groups, 40 cases in each. Usual treatment group: conventional drugs and CR therapy. EECP treatment group: on the basis of standard treatment group, employ EECP therapy. Comparing the two groups before and after the treatment curative effect cardiac function index, endothelial unction index, adverse cardiovascular events, etc.After EECP treatment, the treatment group showed a higher effective rate compared to the usual treatment group (P < 0.05). EECP group curative effect, left ventricular ejection fraction,plasma NO and vascular endothelial growth factor levels higher than the usual group, the incidence of adverse cardiovascular events is lower than the usual group. The difference was statistically significant (P < 0.05).EECP combined with cardiac rehabilitation in patients with CMD symptoms has better effect and safety and provides reference for treatment of CMD patients.

摘要

增强型体外反搏(EECP)或心脏康复(CR)治疗有益于冠心病患者;本文旨在探讨 EECP 联合 CR 治疗非阻塞性冠心病(NOCAD)和冠状动脉微循环障碍(CMD)患者的可行性。

2021 年 1 月至 2022 年 6 月,我们以 NOCAD 患者为研究对象,行心脏磁共振(CMR)、心肌灌注储备(MPR)<2.0 有冠状动脉微循环障碍(CMD)患者 80 例。采用随机指标法将 80 例 CMD 患者分为两组,每组 40 例。常规治疗组:常规药物和 CR 治疗。EECP 治疗组:在标准治疗组基础上采用 EECP 治疗。比较两组治疗前后的疗效、心功能指标、内皮功能指标、心血管不良事件等。

EECP 治疗后,治疗组的有效率明显高于常规治疗组(P<0.05)。EECP 组的疗效、左心室射血分数、血浆 NO 和血管内皮生长因子水平均高于常规组,不良心血管事件的发生率低于常规组。差异有统计学意义(P<0.05)。

EECP 联合心脏康复治疗 CMD 症状患者具有更好的疗效和安全性,为 CMD 患者的治疗提供了参考。

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