School of Biosciences, Faculty of Health and Medicine Sciences, Taylor's University, Subang Jaya, Malaysia.
National Centre for Infectious Diseases, Singapore, Singapore.
Trends Microbiol. 2024 Nov;32(11):1132-1142. doi: 10.1016/j.tim.2024.04.011. Epub 2024 May 14.
Dengue is a mosquito-borne viral disease which causes significant morbidity and mortality each year. Previous research has proposed several mechanisms of pathogenicity that mainly involve the dengue virus and host humoral immunity. However, innate immune cells, such as neutrophils, may also play an important role in dengue, albeit a much less defined role. In this review, we discuss the emerging roles of neutrophils in dengue and their involvement in pathologies associated with severe dengue. We also describe the potential use of several neutrophil proteins as biomarkers for severe dengue. These studies suggest that neutrophils are important players in dengue, and a better understanding of neutrophil-dengue biology is urgently needed.
登革热是一种由蚊子传播的病毒性疾病，每年都会导致大量的发病率和死亡率。先前的研究提出了几种致病性机制，主要涉及登革病毒和宿主体液免疫。然而，中性粒细胞等先天免疫细胞也可能在登革热中发挥重要作用，尽管作用不太明确。在这篇综述中，我们讨论了中性粒细胞在登革热中的新作用及其在与重症登革热相关的病理中的参与。我们还描述了几种中性粒细胞蛋白作为重症登革热生物标志物的潜在用途。这些研究表明，中性粒细胞是登革热的重要参与者，迫切需要更好地了解中性粒细胞与登革热的生物学关系。
