聚乙烯醇系膜定位对肾小球基底膜厚度的影响。

Effects of mesangial localization of polyvinyl alcohols on glomerular basement membrane thickness.

作者信息

Mauer S M, Steffes M W, Brown D M

出版信息

Kidney Int. 1985 May;27(5):751-5. doi: 10.1038/ki.1985.75.

DOI:10.1038/ki.1985.75

Abstract

We studied the effects of mesangial localization of polyvinyl alcohols (PVA) on glomerular basement membrane (GBM) thickness in inbred Lewis rats. To avoid possible influences of PVA redistribution after localization in liver, lung, and other organs, the kidneys of rats given PVA were transplanted into uninephrectomized normal rats. Normal kidneys transplanted into normal rats served as a control. GBM thickness at the time of transplantation was the same in PVA kidneys as in normal kidneys. However, by 18 weeks post-transplant GBM thickness was greater in PVA kidneys, and this increase was sustained at 30 weeks. Within the glomeruli of PVA kidneys, lobules with marked mesangial PVA accumulation had more marked GBM thickening than lobules with little or no PVA accumulation. It is concluded that changes within the mesangium can influence GBM thickness. Whether this represents a direct effect of mesangial architectural distortion, a consequence of local phlogistic activities such as the influx of macrophages into the mesangium of glomeruli with PVA localization, or the result of intraglomerular hemodynamic perturbations is unclear.

摘要

我们研究了聚乙烯醇（PVA）在系膜中的定位对近交系Lewis大鼠肾小球基底膜（GBM）厚度的影响。为避免PVA在肝脏、肺和其他器官定位后重新分布可能产生的影响，将给予PVA的大鼠的肾脏移植到单侧肾切除的正常大鼠体内。移植到正常大鼠体内的正常肾脏作为对照。移植时，PVA肾脏的GBM厚度与正常肾脏相同。然而，移植后18周，PVA肾脏的GBM厚度更大，且这种增加在30周时持续存在。在PVA肾脏的肾小球内，系膜PVA积累明显的小叶比PVA积累很少或没有积累的小叶有更明显的GBM增厚。得出的结论是，系膜内的变化可影响GBM厚度。目前尚不清楚这是系膜结构扭曲的直接作用、局部炎症活动（如巨噬细胞流入伴有PVA定位的肾小球系膜）的结果，还是肾小球内血流动力学紊乱的结果。