• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Repurposing pexmetinib as an inhibitor of TKI-resistant BCR::ABL1.

作者信息

Fontana Diletta, Malighetti Federica, Villa Matteo, Zambon Alfonso, Gambacorti-Passerini Carlo, Mologni Luca

机构信息

Department of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.

Department of Chemistry and Geological Sciences, University of Modena and Reggio Emilia, Modena, Italy.

出版信息

Leukemia. 2024 Aug;38(8):1843-1847. doi: 10.1038/s41375-024-02282-y. Epub 2024 May 15.

DOI:10.1038/s41375-024-02282-y
PMID:38750137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11286508/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c5/11286508/69249b89e199/41375_2024_2282_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c5/11286508/9442e7283696/41375_2024_2282_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c5/11286508/69249b89e199/41375_2024_2282_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c5/11286508/9442e7283696/41375_2024_2282_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/43c5/11286508/69249b89e199/41375_2024_2282_Fig2_HTML.jpg

相似文献

1
Repurposing pexmetinib as an inhibitor of TKI-resistant BCR::ABL1.将培美替尼重新用作TKI耐药性BCR::ABL1的抑制剂。
Leukemia. 2024 Aug;38(8):1843-1847. doi: 10.1038/s41375-024-02282-y. Epub 2024 May 15.
2
Mechanisms of Resistance to ABL Kinase Inhibition in Chronic Myeloid Leukemia and the Development of Next Generation ABL Kinase Inhibitors.慢性髓性白血病中对ABL激酶抑制的耐药机制及下一代ABL激酶抑制剂的研发
Hematol Oncol Clin North Am. 2017 Aug;31(4):589-612. doi: 10.1016/j.hoc.2017.04.007.
3
Axl Blockade by BGB324 Inhibits BCR-ABL Tyrosine Kinase Inhibitor-Sensitive and -Resistant Chronic Myeloid Leukemia.BGB324 抑制 Axl 阻断可抑制 BCR-ABL 酪氨酸激酶抑制剂敏感和耐药的慢性髓性白血病。
Clin Cancer Res. 2017 May 1;23(9):2289-2300. doi: 10.1158/1078-0432.CCR-16-1930. Epub 2016 Nov 17.
4
Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation.阿昔替尼通过独特的结合构象有效抑制 BCR-ABL1(T315I)。
Nature. 2015 Mar 5;519(7541):102-5. doi: 10.1038/nature14119. Epub 2015 Feb 9.
5
Finding the right BCR-ABL1 tyrosine kinase inhibitor: a case report of successful treatment of a patient with chronic myeloid leukemia and a V299L mutation using nilotinib.找到合适的 BCR-ABL1 酪氨酸激酶抑制剂:使用尼洛替尼成功治疗携带 V299L 突变的慢性髓性白血病患者的病例报告。
BMC Cancer. 2018 Nov 12;18(1):1097. doi: 10.1186/s12885-018-5004-3.
6
Novel tyrosine kinase inhibitors in the treatment of chronic myeloid leukemia.新型酪氨酸激酶抑制剂在慢性髓性白血病治疗中的应用
Expert Rev Hematol. 2021 Nov;14(11):975-978. doi: 10.1080/17474086.2021.1990034. Epub 2021 Oct 20.
7
BCR-ABL truncation due to premature translation termination as a mechanism of resistance to kinase inhibitors.由于过早的翻译终止导致的BCR-ABL截短作为对激酶抑制剂耐药的一种机制。
Acta Haematol. 2009;121(1):27-31. doi: 10.1159/000210060. Epub 2009 Mar 31.
8
Emergence of secondary fusions in chronic myeloid leukemia as a driver of tyrosine kinase inhibitor resistance and blast crisis transformation.慢性髓性白血病中继发性融合作为酪氨酸激酶抑制剂耐药和急变期转化驱动因素的出现。
Leuk Res. 2024 Feb;137:107439. doi: 10.1016/j.leukres.2024.107439. Epub 2024 Jan 23.
9
Response and Resistance to BCR-ABL1-Targeted Therapies.BCR-ABL1 靶向治疗的反应和耐药性。
Cancer Cell. 2020 Apr 13;37(4):530-542. doi: 10.1016/j.ccell.2020.03.006.
10
BCR-ABL1 compound mutations drive ponatinib resistance.BCR-ABL1 复合突变导致 ponatinib 耐药。
Cancer Discov. 2014 Nov;4(11):OF13. doi: 10.1158/2159-8290.CD-RW2014-186. Epub 2014 Sep 4.

本文引用的文献

1
Asciminib: a new therapeutic option in chronic-phase CML with treatment failure.阿西替尼:治疗失败的慢性期 CML 的新治疗选择。
Blood. 2022 Jun 16;139(24):3474-3479. doi: 10.1182/blood.2021014689.
2
Development of asciminib, a novel allosteric inhibitor of BCR-ABL1.ASCIMIB 的研发:一种新型的 BCR-ABL1 变构抑制剂。
Crit Rev Oncol Hematol. 2022 Mar;171:103580. doi: 10.1016/j.critrevonc.2022.103580. Epub 2022 Jan 10.
3
Chronic myeloid leukemia: 2020 update on diagnosis, therapy and monitoring.慢性髓性白血病:诊断、治疗和监测的 2020 更新。
Am J Hematol. 2020 Jun;95(6):691-709. doi: 10.1002/ajh.25792. Epub 2020 Apr 10.
4
Imatinib treatment of paediatric Philadelphia chromosome-positive acute lymphoblastic leukaemia (EsPhALL2010): a prospective, intergroup, open-label, single-arm clinical trial.伊马替尼治疗儿童费城染色体阳性急性淋巴细胞白血病(EsPhALL2010):一项前瞻性、多组、开放标签、单臂临床试验。
Lancet Haematol. 2018 Dec;5(12):e641-e652. doi: 10.1016/S2352-3026(18)30173-X.
5
Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial.达沙替尼治疗费城染色体阳性白血病的疗效和安全性:2 期 PACE 试验的最终 5 年结果。
Blood. 2018 Jul 26;132(4):393-404. doi: 10.1182/blood-2016-09-739086. Epub 2018 Mar 22.
6
Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia.培西美替尼:一种新型的Tie2和p38丝裂原活化蛋白激酶双重抑制剂,在骨髓增生异常综合征和急性髓系白血病的临床前模型中具有疗效。
Cancer Res. 2016 Aug 15;76(16):4841-4849. doi: 10.1158/0008-5472.CAN-15-3062. Epub 2016 Jun 10.
7
An exploratory, randomized, parallel-group, open-label, relative bioavailability study with an additional two-period crossover food-effect study exploring the pharmacokinetics of two novel formulations of pexmetinib (ARRY-614).一项探索性、随机、平行组、开放标签的相对生物利用度研究,并附加一项两周期交叉食物效应研究,以探究培美替尼(ARRY-614)两种新型制剂的药代动力学。
Clin Pharmacol. 2015 Sep 30;7:87-95. doi: 10.2147/CPAA.S83871. eCollection 2015.
8
NPM/ALK mutants resistant to ASP3026 display variable sensitivity to alternative ALK inhibitors but succumb to the novel compound PF-06463922.对ASP3026耐药的NPM/ALK突变体对其他ALK抑制剂表现出不同程度的敏感性,但会被新型化合物PF-06463922所抑制。
Oncotarget. 2015 Mar 20;6(8):5720-34. doi: 10.18632/oncotarget.3122.
9
Axitinib effectively inhibits BCR-ABL1(T315I) with a distinct binding conformation.阿昔替尼通过独特的结合构象有效抑制 BCR-ABL1(T315I)。
Nature. 2015 Mar 5;519(7541):102-5. doi: 10.1038/nature14119. Epub 2015 Feb 9.
10
A phase I study of oral ARRY-614, a p38 MAPK/Tie2 dual inhibitor, in patients with low or intermediate-1 risk myelodysplastic syndromes.一项关于口服ARRY-614(一种p38丝裂原活化蛋白激酶/血管内皮生长因子受体2双抑制剂)用于低危或中危-1骨髓增生异常综合征患者的I期研究。
Clin Cancer Res. 2015 Mar 1;21(5):985-94. doi: 10.1158/1078-0432.CCR-14-1765. Epub 2014 Dec 5.