Albayrak Aslınur, Erbay Bahar, Kayıkçıoğlu Erkan
Department of Clinical Pharmacy, Faculty of Pharmacy, Suleyman Demirel University, Isparta, Turkey.
Faculty of Pharmacy, Suleyman Demirel University, Isparta, Turkey.
J Oncol Pharm Pract. 2025 Jul;31(5):693-699. doi: 10.1177/10781552241255140. Epub 2024 May 16.
IntroductionThis study aimed to determine polypharmacy, potentially inappropriate medications, and potential drug-drug interactions in elderly patients hospitalized in the oncology services of a university hospital in Turkey.MethodsThis retrospective cross-sectional study was conducted between September 2021 and September 2022 on cancer patients over 65 years old hospitalized at Suleyman Demirel University Medical Faculty Hospital in Isparta, Turkey. Potentially inappropriate medications were defined according to the 2023 Beers Criteria of the American Geriatrics Society. Potential drug-drug interactions were determined with Medscape® drug interaction checker.ResultsThe median (min-max) of drugs used by the patients was 6 (2-15). Most of the patients (74.3%) had polypharmacy. Approximately half of the patients (51.4%) had potentially inappropriate medications. The most commonly used potentially inappropriate medications were diuretics (22.1%), metoclopramide (11.4%), antidepressant drugs (7.9%), and opioids (6.4%). The presence of comorbidities, mental, behavioral, and neurodevelopmental disorders, circulatory system diseases, and respiratory system diseases were found to be statistically significantly higher in the group with potentially inappropriate medication than in the group without potentially inappropriate medication ( < 0.05). In total, 98 patients (70%) had at least one potential drug-drug interaction. Potential drug-drug interactions were minor in 33.3%, major in 57.5%, serious in 7.74%, and contraindicated in 0.22%ConclusionAccording to our study, polypharmacy, potentially inappropriate medications, and potential drug-drug interactions were high in elderly cancer patients. It is important to determine potential drug-drug interactions and potentially inappropriate medications in cancer patients by a multidisciplinary team, including the clinical pharmacist, to prevent possible negative consequences.
引言
本研究旨在确定土耳其一家大学医院肿瘤科室住院老年患者的多重用药情况、潜在不适当用药以及潜在药物相互作用。
方法
本回顾性横断面研究于2021年9月至2022年9月在土耳其伊斯帕尔塔的苏莱曼·德米雷尔大学医学院医院对65岁以上的癌症患者进行。潜在不适当用药根据美国老年医学会2023年《Beers标准》定义。潜在药物相互作用通过Medscape®药物相互作用检查器确定。
结果
患者使用药物的中位数（最小值 - 最大值）为6（2 - 15）。大多数患者（74.3%）存在多重用药情况。约一半患者（51.4%）有潜在不适当用药。最常用的潜在不适当用药是利尿剂（22.1%）、甲氧氯普胺（11.4%）、抗抑郁药（7.9%）和阿片类药物（6.4%）。发现存在潜在不适当用药的组中，合并症、精神、行为和神经发育障碍、循环系统疾病以及呼吸系统疾病的发生率在统计学上显著高于无潜在不适当用药的组（<0.05）。共有98名患者（70%）至少存在一种潜在药物相互作用。潜在药物相互作用中，轻度的占33.3%，重度的占57.5%，严重的占7.74%，禁忌的占0.22%。
结论
根据我们的研究，老年癌症患者中多重用药、潜在不适当用药以及潜在药物相互作用的情况较为普遍。由包括临床药师在内的多学科团队确定癌症患者的潜在药物相互作用和潜在不适当用药，以预防可能的不良后果，这一点很重要。
