Espinoza Bertha, Rangel-Flores Hilda, Saucedo-Arteaga Gabriel, Martínez Ignacio, Aguilar-Salinas Carlos A, Cabrera-Mendoza Brenda, Ponce-Patiño David, Mendoza-Duarter Javier, Martínez-Rangel Carlos Eduardo
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, UNAM, Ciudad de México 04010, Mexico.
Centro de Investigación Sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública (INSP), Cuernavaca, Morelos 62100, Mexico.
J Parasitol Res. 2024 May 8;2024:2014142. doi: 10.1155/2024/2014142. eCollection 2024.
Mexican Afro-descendant is a population poorly studied in many aspects, between them the infectious diseases that they suffer. This population is mainly found in the country's Pacific (Oaxaca and Guerrero states) and Atlantic (Veracruz) coast. In these regions, a diversity of triatomine vectors of the Chagas disease is found. Also, all the genotypes of DTUs have been reported. That is why the present study aimed to study the presence of antibodies against and cardiac pathology associated with the Chagas disease in the Mexican Afro-descendant population of Guerrero and Oaxaca. ELISA, Western blot, and recombinant antigen's ELISA were used to evaluate the seropositivity of these communities. Furthermore, an electrocardiographic study and evaluation of risk factors associated with infection in the Oaxaca and Guerrero populations were conducted. 26.77% of the analyzed population was positive for two serological tests. These percentages are higher than the previously reported for the mestizo population in similar studies. Electrocardiographic results showed cardiac disorder associated with the Chagas disease in the population. Also, risk factors were identified associated with the men's activities in the outdoor working areas.
墨西哥非裔后裔在许多方面都缺乏研究，其中包括他们所患的传染病。这一人群主要分布在该国的太平洋沿岸（瓦哈卡州和格雷罗州）和大西洋沿岸（韦拉克鲁斯州）。在这些地区，发现了多种恰加斯病的锥蝽传播媒介。此外，还报告了所有基因型的离散型单位（DTUs）。这就是为什么本研究旨在研究格雷罗州和瓦哈卡州的墨西哥非裔后裔人群中抗恰加斯病抗体的存在情况以及与恰加斯病相关的心脏病理学。采用酶联免疫吸附测定（ELISA）、蛋白质印迹法和重组抗原ELISA来评估这些社区的血清阳性率。此外，还对瓦哈卡州和格雷罗州人群进行了心电图研究以及与感染相关的危险因素评估。在接受分析的人群中，26.77%的人两项血清学检测呈阳性。这些百分比高于之前在类似研究中报道的混血人群的百分比。心电图结果显示该人群中存在与恰加斯病相关的心脏疾病。此外，还确定了与男性在户外工作区域的活动相关的危险因素。
