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溶骨性病变作为急性髓系白血病的首发体征：一例报告

Osteolytic lesions as a presenting sign of acute myeloid leukemia: a case report.

作者信息

Zhang Jingqian, Mu Shidai, Cai Li, Ai Lisha, Wu Yaohui

机构信息

Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Key Lab of Molecular Biological Targeted Therapies of the Ministry of Education, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

出版信息

Front Oncol. 2024 May 1;14:1364266. doi: 10.3389/fonc.2024.1364266. eCollection 2024.

DOI:10.3389/fonc.2024.1364266
PMID:38751817
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11094210/
Abstract

Osteolytic lesions are infrequently observed in adult patients with acute myeloid leukemia (AML). This report details the case of a 66-year-old male patient who presented with myeloid sarcoma (MS), osteolytic lesion and pancytopenia. Effective treatments were delayed due to diagnostic challenges and the rapid progression of the disease. It is essential to consider AML in the differential diagnosis when faced with a patient presenting osteolytic lesions and pancytopenia.

摘要

溶骨性病变在成年急性髓系白血病（AML）患者中并不常见。本报告详细介绍了一名66岁男性患者的病例，该患者表现为髓系肉瘤（MS）、溶骨性病变和全血细胞减少。由于诊断困难和疾病快速进展，有效的治疗被延误。当面对出现溶骨性病变和全血细胞减少的患者时，在鉴别诊断中考虑AML至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc92/11094210/15a27f25a231/fonc-14-1364266-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc92/11094210/15a27f25a231/fonc-14-1364266-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc92/11094210/15a27f25a231/fonc-14-1364266-g002.jpg

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本文引用的文献

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Myeloid sarcoma, chloroma, or extramedullary acute myeloid leukemia tumor: A tale of misnomers, controversy and the unresolved.髓系肉瘤、绿色瘤或髓外急性髓系白血病肿瘤：一个关于误称、争议与未解之谜的故事。
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美国髓外髓样肉瘤的临床特征与结局：基于全国数据集的分析
Blood Cancer J. 2017 Aug 25;7(8):e592. doi: 10.1038/bcj.2017.79.
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Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of 18F-FDG PET/CT.伴有肿块和溶骨性病变的费城染色体阳性急性髓细胞白血病：18F-FDG PET/CT 的发现。
Front Med. 2017 Sep;11(3):440-444. doi: 10.1007/s11684-017-0523-x. Epub 2017 May 27.
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Clinicopathological, Cytogenetic, and Prognostic Analysis of 131 Myeloid Sarcoma Patients.131例髓系肉瘤患者的临床病理、细胞遗传学及预后分析
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Extensive Bone Marrow Necrosis and Osteolytic Lesions in a Case of Acute Myeloid Leukemia Transformed from Polycythemia Vera.真性红细胞增多症转化为急性髓系白血病病例中的广泛骨髓坏死和溶骨性病变
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Osteolytic Bone Lesions - A Rare Presentation of AML M6.溶骨性骨病变——急性髓系白血病M6型的一种罕见表现
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