Xiamen Key Laboratory of Clinical Efficacy and Evidence Studies of Traditional Chinese Medicine, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Department of Gastrointestinal Oncology Surgery, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Front Endocrinol (Lausanne). 2024 May 1;15:1385756. doi: 10.3389/fendo.2024.1385756. eCollection 2024.
Is metastatic breast cancer (dnMBC) the same disease in the elderly as in younger breast cancer remains unclear. This study aimed to determine the metastatic patterns and survival outcomes in dnMBC according to age groups.
We included patients from the Surveillance Epidemiology and End Results program. Chi-square test, multivariate logistic regression analyses, and multivariate Cox regression models were used for statistical analyses.
A total of 17719 patients were included. There were 3.6% (n=638), 18.6% (n=3290), 38.0% (n=6725), and 39.9% (n=7066) of patients aged <35, 35-49, 50-64, and ≥65 years, respectively. Older patients had a significantly higher risk of lung metastasis and a significantly lower risk of liver metastasis. There were 19.1%, 25.6%, 30.9%, and 35.7% of patients with lung metastasis in those aged <35, 35-49, 50-64, and ≥65 years, respectively. Moreover, the proportion of liver metastasis was 37.6%, 29.5%, 26.3%, and 19.2%, respectively. Age was the independent prognostic factor associated with breast cancer-specific survival (BCSS) and overall survival (OS). Those aged 50-64 years had significantly inferior BCSS (P<0.001) and OS (P<0.001) than those aged <35 years. Patients aged ≥65 years also had significantly lower BCSS (P<0.001) and OS (P<0.001) than those aged <35 years. However, similar outcomes were found between those aged 35-49 and <35 years.
Our study suggests that different age groups may affect the metastatic patterns among patients with dnMBC and the survival of younger patients is more favorable than those of older patients.
转移性乳腺癌（dnMBC）在老年人和年轻乳腺癌患者中是否为同一疾病仍不清楚。本研究旨在根据年龄组确定 dnMBC 的转移模式和生存结果。
我们纳入了来自监测、流行病学和最终结果（SEER）计划的患者。采用卡方检验、多变量逻辑回归分析和多变量 Cox 回归模型进行统计学分析。
共纳入 17719 例患者。年龄<35 岁、35-49 岁、50-64 岁和≥65 岁的患者分别占 3.6%（n=638）、18.6%（n=3290）、38.0%（n=6725）和 39.9%（n=7066）。老年患者发生肺转移的风险显著升高，而发生肝转移的风险显著降低。年龄<35 岁、35-49 岁、50-64 岁和≥65 岁的患者中，分别有 19.1%、25.6%、30.9%和 35.7%的患者发生肺转移。此外，肝转移的比例分别为 37.6%、29.5%、26.3%和 19.2%。年龄是与乳腺癌特异性生存（BCSS）和总生存（OS）相关的独立预后因素。50-64 岁年龄组的 BCSS（P<0.001）和 OS（P<0.001）显著低于<35 岁年龄组。≥65 岁年龄组的 BCSS（P<0.001）和 OS（P<0.001）也显著低于<35 岁年龄组。然而，35-49 岁年龄组与<35 岁年龄组的结果相似。
本研究表明，不同年龄组可能影响 dnMBC 患者的转移模式，年轻患者的生存情况优于老年患者。
