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深入了解史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症的皮肤发病机制可以为新的治疗策略提供启示：全面综述。

Greater mechanistic understanding of the cutaneous pathogenesis of Stevens-Johnson syndrome/toxic epidermal necrolysis can shed light on novel therapeutic strategies: a comprehensive review.

机构信息

Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.

Department of Pharmacology and Therapeutics, Ebonyi State University, Abakaliki, Nigeria.

出版信息

Curr Opin Allergy Clin Immunol. 2024 Aug 1;24(4):218-227. doi: 10.1097/ACI.0000000000000993. Epub 2024 May 17.

DOI:10.1097/ACI.0000000000000993
PMID:38753537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11213502/
Abstract

PURPOSE OF REVIEW

Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) are severe cutaneous adverse drug reactions (SCARs) characterized by widespread epithelial detachment and blistering, which affects the skin and mucocutaneous membranes. To date, therapeutic interventions for SJS/TEN have focused on systematic suppression of the inflammatory response using high-dose corticosteroids or intravenous immunoglobulin G (IgG), for example. No targeted therapies for SJS/TEN currently exist.

RECENT FINDINGS

Though our understanding of the pathogenesis of SJS/TEN has advanced from both an immunological and dermatological perspective, this knowledge is yet to translate into the development of new targeted therapies.

SUMMARY

Greater mechanistic insight into SJS/TEN would potentially unlock new opportunities for identifying or repurposing targeted therapies to limit or even prevent epidermal injury and blistering.

摘要

目的综述

史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症（SJS/TEN）是一种严重的药物不良反应（SCARs），其特征为广泛的上皮细胞脱离和水疱形成，影响皮肤和黏膜。迄今为止，SJS/TEN 的治疗干预措施主要集中在使用大剂量皮质类固醇或静脉注射免疫球蛋白 G（IgG）等系统性抑制炎症反应上。目前尚无针对 SJS/TEN 的靶向治疗方法。

最新发现

尽管我们从免疫学和皮肤病学的角度对 SJS/TEN 的发病机制有了更深入的了解，但这些知识尚未转化为新的靶向治疗方法的开发。

总结

对 SJS/TEN 的机制有更深入的了解，可能会为识别或重新利用靶向治疗方法提供新的机会，以限制甚至预防表皮损伤和水疱形成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed52/11213502/b1395b2fed44/coaci-24-218-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed52/11213502/a979db6a38d7/coaci-24-218-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed52/11213502/1df9338b72b3/coaci-24-218-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed52/11213502/b1395b2fed44/coaci-24-218-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed52/11213502/a979db6a38d7/coaci-24-218-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed52/11213502/1df9338b72b3/coaci-24-218-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed52/11213502/b1395b2fed44/coaci-24-218-g003.jpg

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