From the Department of Radiology, University of Pennsylvania, Philadelphia, PA.
Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.
Cancer J. 2024;30(3):159-169. doi: 10.1097/PPO.0000000000000716.
Imaging glucose metabolism with [18F]fluorodeoxyglucose positron emission tomography has transformed the diagnostic and treatment algorithms of numerous malignancies in clinical practice. The cancer phenotype, though, extends beyond dysregulation of this single pathway. Reprogramming of other pathways of metabolism, as well as altered perfusion and hypoxia, also typifies malignancy. These features provide other opportunities for imaging that have been developed and advanced into humans. In this review, we discuss imaging metabolism, perfusion, and hypoxia in cancer, focusing on the underlying biology to provide context. We conclude by highlighting the ability to image multiple facets of biology to better characterize cancer and guide targeted treatment.
使用 [18F]氟代脱氧葡萄糖正电子发射断层扫描成像来检测葡萄糖代谢已经改变了临床实践中许多恶性肿瘤的诊断和治疗策略。然而，肿瘤表型并不仅限于该单一途径的失调。其他代谢途径的重编程以及血流灌注和缺氧的改变也是恶性肿瘤的典型特征。这些特征为已经在人体中开发和推进的其他成像机会提供了可能。在这篇综述中，我们讨论了癌症中的代谢、灌注和缺氧成像，重点介绍了潜在的生物学知识以提供背景信息。最后，我们强调了能够对多个生物学方面进行成像以更好地对肿瘤进行特征描述和指导靶向治疗的能力。
