Knight S C, Bedford P, Hunt R
Cell Immunol. 1985 Sep;94(2):435-9. doi: 10.1016/0008-8749(85)90267-9.
Twenty-four hours after skin painting nude mice with picryl chloride, there was an increase in the number of dendritic cells (DC) isolated from the draining lymph nodes. This increased inflow or retention of DC in lymph nodes following skin painting is therefore unlikely to depend on interaction of DC with T cells. The DC obtained initiated primary proliferative responses in vitro in lymph node cells from congenic euthymic mice. Contact sensitivity developed in congenic mice when they received footpad injections of 60,000 DC from the lymph nodes of nude mice skin sensitized 1 day previously with picryl chloride or oxazolone. The initiation of delayed hypersensitivity was therefore independent of T-cell contamination within the donor DC.
在用苦味酸氯对裸鼠进行皮肤涂抹24小时后，从引流淋巴结中分离出的树突状细胞（DC）数量增加。因此，皮肤涂抹后淋巴结中DC流入或滞留的增加不太可能取决于DC与T细胞的相互作用。所获得的DC在体外引发了同基因正常胸腺小鼠淋巴结细胞的原发性增殖反应。当同基因小鼠接受足垫注射来自1天前用苦味酸氯或恶唑酮致敏的裸鼠淋巴结的60,000个DC时，发生了接触性敏感。因此，迟发型超敏反应的起始不依赖于供体DC内的T细胞污染。
