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呼吸道上皮性腺瘤样错构瘤:鼻窦肿物的一种罕见鉴别诊断。

Respiratory epithelial adenomatoid hamartoma: A rare differential diagnosis of sinonasal mass.

作者信息

Nefzaoui Safa, Zoghlami Imen, Gharsalli Jihene, Sabehi Emna, Romdhane Nadia, Helal Imen, Chiboub Dorra, Hariga Ines, Mbarek Chiraz

机构信息

Otorhinolaryngology and Head and Neck Surgery Department, Habib Thameur Hospital, Tunis, Tunisia.

Anatomic Pathology Department, Habib Thameur Hospital, Tunis, Tunisia.

出版信息

Rare Tumors. 2024 May 14;16:20363613241255567. doi: 10.1177/20363613241255567. eCollection 2024.


DOI:10.1177/20363613241255567
PMID:38756436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11097725/
Abstract

Sino-nasal respiratory epithelial adenomatoid hamartomas (REAHs) are rare entity. They are benign tumors with excellent results after complete excision. We report a case of a 57-year-old male with a history of endoscopic surgery for right nasal polyps 20 years ago. The patient presented nasal obstruction that persisted for 10 years without anosmia nor epistaxis. Nasal endoscopy found a tissular mass filling the right nasal cavity extending to the nasopharynx. CT scan and MRI demonstrated soft tissue opacification of the right maxillary sinus and the homolateral anterior ethmoid cells with extension to the nasal cavity. The suspected diagnosis on imaging was an Inverted papilloma with a wide implantation base on the posterior part of the nasal septum. No endocranial or orbital extension was noted. The patient underwent endoscopic sinus surgery with complete extirpation of the tumor and a right ethmoidectomy. Histopathological assessment showed features consistent with REAH. No recurrence was noted at 1 year follow-up.

摘要

鼻窦呼吸上皮腺样错构瘤(REAHs)是一种罕见的疾病。它们是良性肿瘤,完整切除后效果良好。我们报告一例57岁男性,20年前有右侧鼻息肉内镜手术史。患者出现鼻塞10年,无嗅觉减退或鼻出血。鼻内镜检查发现一个组织块充满右侧鼻腔并延伸至鼻咽部。CT扫描和MRI显示右侧上颌窦及同侧前筛窦软组织混浊并延伸至鼻腔。影像学上疑似诊断为内翻性乳头状瘤,在鼻中隔后部有一个宽基底植入。未发现颅内或眶内侵犯。患者接受了内镜鼻窦手术,肿瘤完整切除并进行了右侧筛窦切除术。组织病理学评估显示符合REAH的特征。随访1年未发现复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da66/11097725/abaa98b75c4b/10.1177_20363613241255567-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da66/11097725/86e8d58d0771/10.1177_20363613241255567-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da66/11097725/e168ca0e48ff/10.1177_20363613241255567-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da66/11097725/abaa98b75c4b/10.1177_20363613241255567-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da66/11097725/86e8d58d0771/10.1177_20363613241255567-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da66/11097725/e168ca0e48ff/10.1177_20363613241255567-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da66/11097725/abaa98b75c4b/10.1177_20363613241255567-fig3.jpg

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引用本文的文献

[1]
Treatment Outcomes of Sinonasal Seromucinous Hamartoma: A Single-Center Experience.

J Rhinol. 2025-7

本文引用的文献

[1]
A case report of adolescent respiratory epithelial adenomatoid hamartoma.

Ear Nose Throat J. 2025-3

[2]
Is Respiratory Epithelial Adenomatoid Hamartoma Related to Central Compartment Atopic Disease?

Am J Rhinol Allergy. 2020-9

[3]
Respiratory Epithelial Adenomatoid Hamartoma: An Important Differential of Sinonasal Masses.

Cureus. 2018-4-17

[4]
Respiratory epithelial adenomatoid hamartoma of the nose: an updated review.

Am J Rhinol Allergy. 2014

[5]
Sinonasal respiratory epithelial adenomatoid hamartomas: series of 51 cases and literature review.

Am J Rhinol Allergy. 2013

[6]
The presentation and clinical significance of sinonasal respiratory epithelial adenomatoid hamartoma (REAH).

Int Forum Allergy Rhinol. 2012-10-4

[7]
Respiratory epithelial adenomatoid hamartomas.

Laryngoscope. 2011-10-17

[8]
Respiratory epithelial adenomatoid hamartomas of the olfactory clefts.

Eur Arch Otorhinolaryngol. 2011-8-30

[9]
Tumor suppressor gene alterations in respiratory epithelial adenomatoid hamartoma (REAH): comparison to sinonasal adenocarcinoma and inflamed sinonasal mucosa.

Am J Surg Pathol. 2006-12

[10]
Respiratory epithelial adenomatoid hamartomas of the sinonasal tract and nasopharynx: a clinicopathologic study of 31 cases.

Ann Otol Rhinol Laryngol. 1995-8

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