Fuchs Kárita da Mata, Pereira Keylla Helena Nobre Pacífico, Xavier Gleice Mendes, Mendonça Júlia Cosenza, Barreto Renata Oliveira, Silva Renata Cesar, de Souza Fabiana Ferreira, Lourenço Maria Lucia Gomes
Veterinary Neonatology Research Group, Department of Veterinary Clinic, School of Veterinary Medicine and Animal Science, São Paulo State University - Unesp, Botucatu, Brazil.
Department of Veterinary Surgery and Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University - Unesp, Botucatu, Brazil.
Front Vet Sci. 2024 May 2;11:1345933. doi: 10.3389/fvets.2024.1345933. eCollection 2024.
Hypoglycemia is the most common metabolic alteration in the clinical routine of newborn dogs, acting as a predictor of mortality in these patients. The neonatal dog shows hepatic insufficiency and homeostatic mechanisms not yet fully developed, with limited glycogen reserves and limited capacity to perform glycogenolysis and gluconeogenesis. These physiological particularities make newborn dogs particularly susceptible to hypoglycemia when of fasting, even for short periods. Several maternal and neonatal factors may be related to a higher risk of developing hypoglycemia in neonates. This paper reviews glycemic homeostasis, the pathophysiology of neonatal hypoglycemia, the main causes involved and the diagnostic and therapeutic approaches to this condition.
低血糖是新生犬临床常规中最常见的代谢改变，是这些患者死亡率的一个预测指标。新生犬表现出肝功能不全且体内稳态机制尚未完全发育，糖原储备有限，糖原分解和糖异生能力有限。这些生理特性使得新生犬即使在短时间禁食时也特别容易发生低血糖。一些母体和新生儿因素可能与新生儿发生低血糖的较高风险有关。本文综述了血糖稳态、新生儿低血糖的病理生理学、相关主要病因以及该病症的诊断和治疗方法。
