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芳香植物环境健康工程(APEHE)是地球系统的一个杠杆点吗?

Is aromatic plants environmental health engineering (APEHE) a leverage point of the earth system?

作者信息

Lu MengYu

机构信息

HEFEI XIAODOUKOU HEALTH TECH CO LTD, China.

出版信息

Heliyon. 2024 May 3;10(9):e30322. doi: 10.1016/j.heliyon.2024.e30322. eCollection 2024 May 15.

DOI:10.1016/j.heliyon.2024.e30322
PMID:38756557
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11096952/
Abstract

It is important to note that every ecological niche in an ecosystem is significant. This study aims to assess the importance of medicinal and aromatic plants (MAPs) in the ecosystem from multiple perspectives. A primary model of Aromatic Plants Environmental Health Engineering (APEHE) has been designed and constructed. The APEHE system was used to collect aerosol compounds, and it was experimentally verified that these compounds have the potential to impact human health by binding to AKT1 as the primary target, and MMP9 and TLR4 as secondary targets. These compounds may indirectly affect human immunity by reversing drug resistance in drug-resistant bacteria in the nasal cavity. This is mainly achieved through combined mutations in sdhA, scrA, and PEP. Our findings are based on Network pharmacology and molecular binding, drug-resistance rescue experiments, as well as combined transcriptomics and metabolomics experiments. It is suggested that APEHE may have direct or indirect effects on human health. We demonstrate APEHE's numerous potential benefits, such as attenuation and elimination of airborne microorganisms in the environment, enhancing carbon and nitrogen storage in terrestrial ecosystems, promoting the formation of low-level clouds and strengthening the virtuous cycle of Earth's ecosystems. APEHE also supports the development of transdisciplinary technologies, including terpene energy production. It facilitates the creation of a sustainable circular economy and provides additional economic advantages through urban optimisation, as well as fresh insights into areas such as the habitability of other planets. APEHE has the potential to serve as a leverage point for the Earth system. We have created a new research direction.

摘要

需要注意的是,生态系统中的每个生态位都很重要。本研究旨在从多个角度评估药用和芳香植物(MAPs)在生态系统中的重要性。已设计并构建了芳香植物环境卫生工程(APEHE)的主要模型。APEHE系统用于收集气溶胶化合物,通过实验验证这些化合物有可能以AKT1作为主要靶点,MMP9和TLR4作为次要靶点与人体健康产生关联。这些化合物可能通过逆转鼻腔耐药菌的耐药性来间接影响人体免疫力。这主要是通过sdhA、scrA和PEP中的联合突变实现的。我们的研究结果基于网络药理学和分子结合、耐药性挽救实验以及转录组学和代谢组学联合实验。结果表明,APEHE可能对人体健康产生直接或间接影响。我们展示了APEHE的诸多潜在益处,例如减少和消除环境中的空气传播微生物、增强陆地生态系统中的碳和氮储存、促进低云形成以及加强地球生态系统的良性循环。APEHE还支持跨学科技术的发展,包括萜烯能源生产。它有助于创建可持续循环经济,并通过城市优化提供额外的经济优势,以及为其他行星的宜居性等领域提供新的见解。APEHE有潜力成为地球系统的一个杠杆点。我们开创了一个新的研究方向。

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