Halberg Franz, Cornélissen Germaine, Regal Philip, Otsuka Kuniaki, Wang Zhengrong, Katinas George Silvestrovitch, Siegelova Jarmila, Homolka Pavel, Prikryl Pavel, Chibisov Sergey Mikhailovich, Holley Daniel C, Wendt Hans W, Bingham Christopher, Palm Sally L, Sonkowsky Robert P, Sothern Robert B, Pales Emil, Mikulecky Miroslav, Tarquini Roberto, Perfetto Federico, Salti Roberto, Maggioni Cristina, Jozsa Rita, Konradov Alexander A, Kharlitskaya Elena Valentinovna, Revillam Miguel, Wan Chaomin, Herold Manfred, Syutkina Elena Vasilievna, Masalov Anatoly Viktorovich, Faraone Piero, Singh Ram Bahadur, Singh R K, Kumar Adarsh, Singhs Ranjana, Sundaram Sasikumar, Sarabandi Tina, Pantaleoni Giancarlo, Watanabe Yoshihiko, Kumagai Yuji, Gubin Denis, Uezono Keiko, Olah Andras, Borer Katarina, Kanabrockia Eugene A, Bathina Srilakshmi, Haus Erhard, Hillman Dewayne, Schwartzkopff Othild, Bakken Earl E, Zeman Michal
Halberg Chronobiology Center, University of Minnesota, Minneapolis, MN, USA.
Biomed Pharmacother. 2004 Oct;58 Suppl 1:S150-87. doi: 10.1016/s0753-3322(04)80025-8.
"Chronoastrobiology: are we at the threshold of a new science? Is there a critical mass for scientific research?" A simple photograph of the planet earth from outer space was one of the greatest contributions of space exploration. It drove home in a glance that human survival depends upon the wobbly dynamics in a thin and fragile skin of water and gas that covers a small globe in a mostly cold and vast universe. This image raised the stakes in understanding our place in that universe, in finding out where we came from and in choosing a path for survival. Since that landmark photograph was taken, new astronomical and biomedical information and growing computer power have been revealing that organic life, including human life, is and has been connected to invisible (non-photic) forces, in that vast universe in some surprising ways. Every cell in our body is bathed in an external and internal environment of fluctuating magnetism. It is becoming clear that the fluctuations are primarily caused by an intimate and systematic interplay between forces within the bowels of the earth--which the great physician and father of magnetism William Gilbert called a 'small magnet'--and the thermonuclear turbulence within the sun, an enormously larger magnet than the earth, acting upon organisms, which are minuscule magnets. It follows and is also increasingly apparent that these external fluctuations in magnetic fields can affect virtually every circuit in the biological machinery to a lesser or greater degree, depending both on the particular biological system and on the particular properties of the magnetic fluctuations. The development of high technology instruments and computer power, already used to visualize the human heart and brain, is furthermore making it obvious that there is a statistically predictable time structure to the fluctuations in the sun's thermonuclear turbulence and thus to its magnetic interactions with the earth's own magnetic field and hence a time structure to the magnetic fields in organisms. Likewise in humans, and in at least those other species that have been studied, computer power has enabled us to discover statistically defined endogenous physiological rhythms and further direct effects that are associated with these invisible geo- and heliomagnetic cycles. Thus, what once might have been dismissed as noise in both magnetic and physiological data does in fact have structure. And we may be at the threshold of understanding the biological and medical meaning and consequences of these patterns and biological-astronomical linkages as well. Structures in time are called chronomes; their mapping in us and around us is called chronomics. The scientific study of chronomes is chronobiology. And the scientific study of all aspects of biology related to the cosmos has been called astrobiology. Hence we may dub the new study of time structures in biology with regard to influences from cosmo- helio- and geomagnetic rhythms chronoastrobiology. It has, of course, been understood for centuries that the movements of the earth in relation to the sun produce seasonal and daily cycles in light energy and that these have had profound effects on the evolution of life. It is now emerging that rhythmic events generated from within the sun itself, as a large turbulent magnet in its own right, can have direct effects upon life on earth. Moreover, comparative studies of diverse species indicate that there have also been ancient evolutionary effects shaping the endogenous chronomic physiological characteristics of life. Thus the rhythms of the sun can affect us not only directly, but also indirectly through the chronomic patterns that solar magnetic rhythms have created within our physiology in the remote past. For example, we can document the direct exogenous effects of given specific solar wind events upon human blood pressure and heart rate. We also have evidence of endogenous internal rhythms in blood pressure and heart rate that are close to but not identical to the period length of rhythms in the solar wind. These were installed genetically by natural selection at some time in the distant geological past. This interpretive model of the data makes the prediction that the internal and external influences on heart rate and blood pressure can reinforce or cancel each other out at different times. A study of extensive clinical and physiological data shows that the interpretive model is robust and that internal and external effects are indeed augmentative at a statistically significant level. Chronoastrobiological studies are contributing to basic science--that is, our understanding is being expanded as we recognize heretofore unelaborated linkages of life to the complex dynamics of the sun, and even to heretofore unelaborated evolutionary phenomena. Once, one might have thought of solar storms as mere transient 'perturbations' to biology, with no lasting importance. Now we are on the brink of understanding that solar turbulences have played a role in shaping endogenous physiological chronomes. There is even documentation for correlations between solar magnetic cycles and psychological swings, eras of belligerence and of certain expressions of sacred or religious feelings. Chronoastrobiology can surely contribute to practical applications as well as to basic science. It can help develop refinements in our ability to live safely in outer space, where for example at the distance of the moon the magnetic influences of the sun will have an effect upon humans unshielded by the earth's native magnetic field. We should be better able to understand these influences as physiological and mechanical challenges, and to improve our estimations of the effects of exposure. Chronoastrobiology moreover holds great promise in broadening our perspectives and powers in medicine and public health right here upon the surface of the earth. Even the potential relevance of chronoastrobiology for practical environmental and agricultural challenges cannot be ruled out at this early stage in our understanding of the apparently ubiquitous effects of magnetism and hence perhaps of solar magnetism on life. The evidence already mentioned that fluctuations in solar magnetism can influence gross clinical phenomena such as rates of strokes and heart attacks, and related cardiovascular variables such as blood pressure and heart rate, should illustrate the point that the door is open to broad studies of clinical implications. The medical value of better understanding magnetic fluctuations as sources of variability in human physiology falls into several categories: 1) The design of improved analytical and experimental controls in medical research. Epidemiological analyses require that the multiple sources causing variability in physiological functions and clinical phenomena be identified and understood as thoroughly as possible, in order to estimate systematic alterations of any one variable. 2) Preventive medicine and the individual patients'care. There are no flat 'baselines', only reference chronomes. Magnetic fluctuations can be shown statistically to exacerbate health problems in some cases. The next step should be to determine whether vulnerable individuals can be identified by individual monitoring. Such vulnerable patients may then discover that they have the option to avoid circumstances associated with anxiety during solar storms, and/or pay special attention to their medication or other treatments. Prehabilitation by self-help can hopefully complement and eventually replace much costly rehabilitation. 3) Basic understanding of human physiological mechanisms. The chronomic organization of physiology implies a much more subtle dynamic integration of functions than is generally appreciated. All three categories of medical value in turn pertain to the challenges for space science of exploring and colonizing the solar system. The earth's native magnetic field acts like an enormous umbrella that offers considerable protection on the surface from harsh solar winds of charged particles and magnetic fluxes. The umbrella becomes weaker with distance from the earth and will offer little protection for humans, other animals, and plants in colonies on the surface of the moon or beyond. Thus it is important before more distant colonization is planned or implemented to better understand those magnetism-related biological- solar interactions that now can be studied conveniently on earth. (ABSTRACT TRUNCATED)
“时间天体生物学:我们正站在一门新科学的门槛上吗?科学研究是否已具备足够的影响力?”一张从外太空拍摄的地球的简单照片,是太空探索最伟大的贡献之一。它一眼就让人深刻认识到,人类的生存依赖于覆盖在一个小星球上的稀薄且脆弱的水和气体外层中不稳定的动态平衡,而这个小星球处于一个大多寒冷且广袤的宇宙之中。这张照片提高了我们理解自身在宇宙中的位置、弄清楚我们从何而来以及选择生存路径的重要性。自从那张具有里程碑意义的照片拍摄以来,新的天文和生物医学信息以及不断增强的计算机能力,一直在揭示包括人类生命在内的有机生命,在那个广袤宇宙中一直以一些惊人的方式与无形(非光)力量相联系。我们身体的每个细胞都沐浴在一个外部和内部磁场波动的环境中。越来越明显的是,这些波动主要是由地球内部的力量——伟大的物理学家和磁学之父威廉·吉尔伯特称之为“小磁体”——与太阳内部的热核湍流之间密切而系统的相互作用引起的,太阳是一个比地球大得多的磁体,作用于生物体,而生物体是微小的磁体。由此可见,并且也越来越明显的是,这些外部磁场波动实际上可以在不同程度上影响生物机器中的每一个电路,这既取决于特定的生物系统,也取决于磁波动的特定属性。高科技仪器和计算机能力的发展,已经用于可视化人类的心脏和大脑,这也进一步表明,太阳热核湍流的波动以及因此其与地球自身磁场的磁相互作用存在统计上可预测的时间结构,进而生物体中的磁场也存在时间结构。同样在人类以及至少那些已被研究的其他物种中,计算机能力使我们能够发现统计上定义的内源性生理节律以及与这些无形的地磁场和日磁场周期相关的进一步直接影响。因此,曾经在磁学和生理学数据中可能被视为噪声的东西,实际上确实具有结构。我们可能正处于理解这些模式和生物 - 天文联系的生物学和医学意义及后果的门槛上。时间中的结构被称为时间组;它们在我们体内和周围的映射被称为时间组学。对时间组的科学研究是时间生物学。而对与宇宙相关的生物学各个方面的科学研究被称为天体生物学。因此,我们可以将关于宇宙 - 日 - 地磁场节律影响的生物学时间结构的新研究称为时间天体生物学。当然,几个世纪以来人们就已经明白,地球相对于太阳的运动在光能方面产生季节性和每日周期,并且这些对生命的进化产生了深远影响。现在正在出现的情况是,太阳自身作为一个巨大的湍流磁体产生的节律事件,可能对地球上的生命产生直接影响。此外,对不同物种的比较研究表明,也存在古老的进化影响塑造了生命的内源性时间组生理特征。因此,太阳的节律不仅可以直接影响我们,还可以通过太阳磁节律在遥远过去在我们生理中创造的时间组模式间接影响我们。例如,我们可以记录特定太阳风事件对人类血压和心率的直接外部影响。我们也有证据表明血压和心率存在内源性内部节律,这些节律与太阳风中节律的周期长度相近但并不完全相同。这些是在遥远的地质过去某个时候通过自然选择遗传设定的。对这些数据的这种解释模型预测,对心率和血压的内部和外部影响在不同时间可能相互增强或抵消。对大量临床和生理数据的研究表明,这种解释模型是可靠的,并且内部和外部影响在统计学显著水平上确实是增强性的。时间天体生物学研究正在为基础科学做出贡献——也就是说,随着我们认识到生命与太阳复杂动态之间迄今未详细阐述的联系,甚至与迄今未详细阐述的进化现象之间的联系,我们的理解正在不断扩展。曾经,人们可能认为太阳风暴只是对生物学的短暂“干扰”,没有持久的重要性。现在我们即将理解太阳湍流在塑造内源性生理时间组方面发挥了作用。甚至有文献记录了太阳磁周期与心理波动、好战时期以及某些神圣或宗教情感表达之间的相关性。时间天体生物学肯定既能为基础科学做出贡献,也能为实际应用做出贡献。它可以帮助我们改进在太空中安全生活的能力,例如在月球距离处,太阳的磁影响将对未受地球本土磁场保护的人类产生影响。我们应该能够更好地将这些影响理解为生理和机械挑战,并改进我们对暴露影响的估计。此外,时间天体生物学在拓宽我们在地球上医学和公共卫生方面的视野和能力方面也具有巨大潜力。即使在我们对磁现象(因此可能还有太阳磁现象)对生命的明显普遍影响的理解的早期阶段,也不能排除时间天体生物学对实际环境和农业挑战的潜在相关性。已经提到的太阳磁波动会影响诸如中风和心脏病发作率等总体临床现象以及诸如血压和心率等相关心血管变量的证据,应该说明对临床影响进行广泛研究的大门是敞开的。更好地将磁波动理解为人类生理变异性来源的医学价值可分为几类:1)医学研究中改进分析和实验控制的设计。流行病学分析要求尽可能全面地识别和理解导致生理功能和临床现象变异性的多种来源,以便估计任何一个变量的系统性变化。2)预防医学和个体患者护理。不存在固定的“基线”,只有参考时间组。在某些情况下,磁波动在统计学上可显示会加剧健康问题。下一步应该是确定是否可以通过个体监测识别出易受影响的个体。然后,这些易受影响的患者可能会发现他们可以选择避免在太阳风暴期间与焦虑相关的情况,和/或特别注意他们的药物治疗或其他治疗。通过自助进行预康复有望补充并最终取代许多昂贵的康复治疗。3)对人类生理机制的基本理解。生理学的时间组组织意味着功能的动态整合比一般认识的要微妙得多。这三类医学价值反过来又与探索和殖民太阳系的空间科学挑战相关。地球的本土磁场就像一把巨大的伞,在地球表面为我们提供了相当大的保护,使其免受带电粒子和磁通量的强烈太阳风的影响。随着距离地球变远,这把伞会变弱,对于月球表面或更远地方的殖民地中的人类、其他动物和植物几乎起不到保护作用。因此,在计划或实施更远距离的殖民之前,更好地理解那些现在可以在地球上方便研究的与磁相关的生物 - 太阳相互作用是很重要的。