Sjölund B H
J Neurosurg. 1985 Oct;63(4):612-6. doi: 10.3171/jns.1985.63.4.0612.
Transcutaneous electrical nerve stimulation (TENS) is now a well established clinical technique to alleviate chronic pain. Its mechanism of action remains unknown and the stimulation parameters used are based on subjective reports from patients. In the present study, a systematic investigation has been performed with conditioning stimulation of different parameters delivered to a dissected skin nerve in the lightly anesthetized rat, utilizing the size of a C-fiber-evoked flexion reflex as a measure of transmission from nociceptive afferent fibers in the spinal cord. A stimulation intensity that recruited both A-beta and A-delta fibers was more effective in depressing the C-fiber-evoked reflex at all frequencies studied than were intensities activating A-beta fibers only. A stimulation frequency of 80 Hz gave the most profound inhibition. The implications for clinical treatment are discussed.
经皮电神经刺激（TENS）现在是一种成熟的缓解慢性疼痛的临床技术。其作用机制尚不清楚，所使用的刺激参数是基于患者的主观报告。在本研究中，对轻度麻醉大鼠的解剖皮肤神经施加不同参数的条件刺激，进行了系统研究，利用C纤维诱发的屈曲反射的大小作为脊髓中伤害性传入纤维传递的指标。在所有研究频率下，募集A-β和A-δ纤维的刺激强度比仅激活A-β纤维的强度更能有效抑制C纤维诱发的反射。80Hz的刺激频率产生的抑制作用最为显著。文中讨论了其对临床治疗的意义。
