Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China.
Department of Rheumatology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Clin Exp Rheumatol. 2024 Jul;42(7):1467-1473. doi: 10.55563/clinexprheumatol/icoqy3. Epub 2024 May 17.
This study explores the clinical characteristics associated with the occurrence of acute anterior uveitis (AAU) in patients with axial spondyloarthritis (axSpA) within a large, multicentre database.
This observational, cross-sectional study of patients with axSpA used data from the Chinese Spondyloarthritis Registry between August 1, 2018, and March 31, 2020. The demographic and clinical features of patients with and without AAU were compared. Univariate and multivariate analyses were performed to determine the association between variables and uveitis.
A total of 4304 patients were included in this study. The prevalence of AAU in patients with axSpA was 10.59%. Multivariate logistic regression analysis revealed a positive correlation between AAU and age at diagnosis (odds ratio [OR], 1.026; p<0.001), disease duration (OR, 2.117; p<0.001), current or past Achilles tendinitis (OR, 1.692; p<0.001), current or past dactylitis (OR, 1.687; p=0.002), current or past psoriasis (OR, 3.932; p<0.001), presence of human leukocyte antigen-B27 (HLA-B27) (OR, 2.787; p<0.001), and a good response to non-steroidal anti-inflammatory drugs (NSAIDs) (OR, 1.343; p=0.027).
AAU was the most common extra-articular manifestation in the Chinese Spondyloarthritis Registry. In Chinese patients with axSpA, older age at diagnosis, longer disease duration, presence of HLA-B27, current or past Achilles tendinitis, current or past dactylitis, current or past psoriasis, and a good response to NSAIDs were positively associated with AAU.
本研究旨在通过大型多中心数据库，探讨与中轴型脊柱关节炎（axSpA）患者发生急性前葡萄膜炎（AAU）相关的临床特征。
本项观察性、横断面研究纳入了 2018 年 8 月 1 日至 2020 年 3 月 31 日中国脊柱关节炎注册中心的数据，分析 axSpA 患者的人口统计学和临床特征，并比较有无 AAU 患者的特征。采用单变量和多变量分析确定变量与葡萄膜炎之间的关联。
本研究共纳入 4304 例患者，axSpA 患者中 AAU 的患病率为 10.59%。多变量 logistic 回归分析显示，AAU 与诊断时年龄（比值比 [OR]，1.026；p<0.001）、疾病病程（OR，2.117；p<0.001）、当前或既往跟腱炎（OR，1.692；p<0.001）、当前或既往掌跖关节炎（OR，1.687；p=0.002）、当前或既往银屑病（OR，3.932；p<0.001）、人类白细胞抗原-B27（HLA-B27）阳性（OR，2.787；p<0.001）和对非甾体抗炎药（NSAIDs）反应良好（OR，1.343；p=0.027）相关。
AAU 是中国脊柱关节炎注册中心最常见的关节外表现。在中国 axSpA 患者中，诊断时年龄较大、疾病病程较长、HLA-B27 阳性、当前或既往跟腱炎、当前或既往掌跖关节炎、当前或既往银屑病以及对 NSAIDs 反应良好与 AAU 呈正相关。
