Department of Clinical Medicine, People's Hospital of Deyang City, Deyang, China.
West China Center of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu, China.
Int Urol Nephrol. 2024 Oct;56(10):3307-3321. doi: 10.1007/s11255-024-04081-x. Epub 2024 May 17.
Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, with an increasing prevalence worldwide, but its pathomechanisms remain incompletely understood. Accumulating evidence suggests that immunity plays an important role in the development of DN. Many papers have been published in the field over the last 20 years, but there has been no bibliometric review of the research hotspots and trends in the field. This study aimed to assess the current research status and future trends of the link between immune and DN using bibliometric analysis.
Publications on the association between immunity and DN from 2004 to 2023 were retrieved from the Web of Science Core Collection database and screened according to inclusion criteria. VOSviewer and CiteSpace software were employed to visualize research trends and hotspots in the field. Data including author, institution, country, journal, reference, and keyword were analyzed.
Ultimately 1246 publications meeting the criteria were included in the bibliometric analysis, involving 838 articles (84.96%) and 408 reviews (15.04%). The literature covered 81 countries and regions, 1751 institutions, and 6584 authors. The top 2 countries in terms of the number of publications were China (435) and the United States (318), and they collaborated most frequently. The United States had the highest number of citations for published papers (18,161), far exceeding the other countries. England had 38 publications but had the highest average number of citations (92.32). The University of California system was the most prolific institution (25 papers, 1062 citations, 42.48 citations per paper). Frontiers in Immunology was the most prolific journal in the field (30 papers). The most cited journal was Kidney International (863 citations). The analysis of keywords and references showed that inflammation, ferroptosis, and lipid metabolism may be future research hotspots in this field.
The number of publications related to immunity and DN has increased annually over the past 20 years, with a significant increase in the last 3 years especially. Our results identified research hotspots and trends in the field. These findings provide valuable perspectives for future research, enhancing our understanding of the immune-related mechanisms of DN and exploring potential therapeutic strategies.
糖尿病肾病（DN）是终末期肾病的主要原因，在全球范围内患病率不断增加，但其发病机制仍不完全清楚。越来越多的证据表明，免疫在 DN 的发生发展中起着重要作用。过去 20 年来，该领域发表了许多论文，但尚未对该领域的研究热点和趋势进行文献计量学综述。本研究旨在使用文献计量学分析评估免疫与 DN 之间联系的当前研究现状和未来趋势。
从 Web of Science 核心合集数据库中检索 2004 年至 2023 年期间与免疫和 DN 相关的出版物，并根据纳入标准进行筛选。使用 Vosviewer 和 Citespace 软件可视化该领域的研究趋势和热点。分析的数据包括作者、机构、国家、期刊、参考文献和关键词。
最终有 1246 篇符合标准的出版物被纳入文献计量分析，其中包括 838 篇文章（84.96%）和 408 篇综述（15.04%）。文献涵盖 81 个国家和地区、1751 个机构和 6584 位作者。发文数量最多的前 2 个国家是中国（435 篇）和美国（318 篇），且合作最为频繁。就发表论文的被引次数而言，美国（18161 次）遥遥领先于其他国家。英国（38 篇）的平均被引次数最高（92.32 次）。加利福尼亚大学系统（25 篇论文，1062 次引用，每篇论文 42.48 次引用）是最活跃的机构。Frontiers in Immunology 是该领域最具影响力的期刊（30 篇）。被引频次最高的期刊是 Kidney International（863 次引用）。关键词和参考文献分析表明，炎症、铁死亡和脂质代谢可能是该领域未来的研究热点。
过去 20 年来，与免疫和 DN 相关的出版物数量逐年增加，尤其是在过去 3 年增长显著。我们的研究结果确定了该领域的研究热点和趋势。这些发现为未来的研究提供了有价值的视角，有助于深入了解 DN 的免疫相关机制，并探索潜在的治疗策略。
