Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Faculty of Medicine, University of Barcelona, Barcelona, Spain; National Department of Health, Aopi Centre, Port Moresby, Papua New Guinea.
Acta Trop. 2024 Aug;256:107254. doi: 10.1016/j.actatropica.2024.107254. Epub 2024 May 16.
The etiological agent of yaws is the spirochete Treponema pallidum (TP) subsp. pertenue (TPE) and infects the children of Papua New Guinea, causing ulcerative skin lesions that impairs normal growth and development. Closely related strains of Treponema pallidum subsp. pertenue, J11, and T13 were detected in an ulcer biospecimen derived from a 5-year-old yaws patient. Cloning experiments validated the presence of two distinct but similar genotypes, namely T13 and J11, co-occurring within a single host. While coinfection with highly related TPE strains has only limited epidemiological and clinical relevance, this is the first documented coinfection with genetically distinct TP strains in a single patient. Similar coinfections in the past were explained by the existence of over a dozen recombinant loci present in the TP genomes as a result of inter-strain or inter-subspecies recombination events following an anticipated scenario of TP coinfection, i.e., uptake of foreign DNA and DNA recombination.
雅司病的病原体是苍白密螺旋体亚种地方性密螺旋体（TP）subsp。 pertenue（TPE），感染巴布亚新几内亚的儿童，导致溃疡性皮肤损伤，影响正常生长发育。从一名 5 岁雅司病患者的溃疡生物标本中检测到与苍白密螺旋体亚种地方性密螺旋体密切相关的菌株 J11 和 T13。克隆实验证实了两种不同但相似的基因型的存在，即 T13 和 J11，在单个宿主中共存。虽然与高度相关的 TPE 菌株的合并感染在流行病学和临床方面只有有限的相关性，但这是首例在单个患者中同时感染具有遗传差异的 TP 菌株的记录。过去类似的合并感染是由于 TP 基因组中存在十几个重组基因座，这是由于菌株间或亚种间重组事件导致的，这是在预期的 TP 合并感染情况下发生的，即摄取外来 DNA 和 DNA 重组。
