Division of Gastroenterology, Hepatology, and Nutrition, University of Minnesota, Minneapolis, Minnesota.
Division of Gastroenterology and Hepatology, University of Illinois, Chicago, Illinois.
Gastroenterology. 2024 Sep;167(4):673-688. doi: 10.1053/j.gastro.2024.02.052. Epub 2024 May 15.
Acute pancreatitis (AP) is increasing in incidence across the world, and in all age groups. Major changes in management have occurred in the last decade. Avoiding total parenteral nutrition and prophylactic antibiotics, avoiding overly aggressive fluid resuscitation, initiating early feeding, avoiding endoscopic retrograde cholangiopancreatography in the absence of concomitant cholangitis, same-admission cholecystectomy, and minimally invasive approaches to infected necrosis should now be standard of care. Increasing recognition of the risk of recurrence of AP, and progression to chronic pancreatitis, along with the unexpectedly high risk of diabetes and exocrine insufficiency after AP is the subject of large ongoing studies. In this review, we provide an update on important changes in management for this increasingly common disease.
急性胰腺炎(AP)在全球范围内的发病率不断增加,且各年龄段均有发病。在过去十年中,其治疗管理发生了重大变化。避免全胃肠外营养和预防性抗生素、避免过度积极的液体复苏、早期开始喂养、在无合并胆管炎的情况下避免内镜逆行胰胆管造影、入院时行胆囊切除术,以及微创处理感染性坏死,这些现在应该是标准治疗方法。越来越多的人认识到 AP 复发和进展为慢性胰腺炎的风险,以及 AP 后糖尿病和外分泌功能不全的风险出乎意料地高,这些都是正在进行的大型研究的主题。在这篇综述中,我们提供了对这种日益常见疾病的治疗管理的重要更新。